| 益肾降脂胶囊对慢性肾功能衰竭大鼠整体肾功能及血脂的影响 |
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| 引用本文： | 刘润侠,吴喜利,刘艳巧,王志勇.益肾降脂胶囊对慢性肾功能衰竭大鼠整体肾功能及血脂的影响[J].中国中医急症,2003,12(3):256-256,258. |
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| 作者姓名： | 刘润侠 吴喜利 刘艳巧 王志勇 |
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| 作者单位： | 西安交通大学第二医院,西安,710004 |
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| 基金项目： | 陕西省科技攻关项目(No.2000K14-G10) |
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| 摘 要： | 目的 观察益肾降脂胶囊对慢性肾功能衰竭(慢性肾衰)大鼠的保护作用，并探讨其治疗机制。方法 复制慢性肾衰大鼠模型，分别给大鼠灌胃益肾降脂胶囊(治疗组)和阳性对照药(阳性对照组)，90d后测大鼠肌酐(SCr)、尿素氮(BUN)及血脂、24h尿蛋白，取肾组织作病理检查；并与空白对照组比较。结果 与阳性对照组比较，治疗组BUN、SCr、24h尿蛋白及血脂降低，肾组织病理损害减轻。结论 益肾降脂胶囊具有降低血脂、改善肾功能、减轻肾间质炎症、促进受损组织恢复的作用。
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| 关 键 词： | 益肾降脂胶囊 慢性肾功能衰竭 大鼠 肾功能 血脂 冬虫夏草 绞股蓝 |
| 文章编号： | 1004-745X(2003)03-0256-02 |
Experimental Study on Effect of Yishenjiangzhi Capsule on the Whole Renal Function and Blood Liqid of the Model of the Chronic Renal Failure in Rats |
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| Liu Runxia,Wu Xili,Wang Zhiyong.Experimental Study on Effect of Yishenjiangzhi Capsule on the Whole Renal Function and Blood Liqid of the Model of the Chronic Renal Failure in Rats[J].Journal of Emergency in Traditional Chinese Medicine,2003,12(3):256-256,258. |
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| Authors: | Liu Runxia Wu Xili Wang Zhiyong |
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| Abstract: | Objective: To observe the effect of Yishenjiangzhi Capsule (YSJZC) on chronic renal failure in rats, and to investigate the treating mechanism. Methods: The model of rat chronic, renal failure (CRF) was made by using adenine. After the treatment of YSJZC for 90 days, the levels of blood urea nitrogen(BUN), serum creatinine(SCr), lipid, proteinurea were measured. And kidney biopsy was also taken and stained with HE, PAS and Masson. Results: YSJZC can lower urea nitragen, serum creatnine, lipid and protein-urea significantly in the treatment groups. Conclusion: YSJZC can lower lipid, improving the whole renal function and pathology. |
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| Keywords: | Yishenjiangzhi Capsule chronic renal failure blood lipid renal function |
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