几种促透剂联合使用对双氯芬酸钠体外经裸小鼠皮肤吸收的影响

目的:研究几种促透剂联合使用对药物体外经皮渗透的影响。方法:在离体透皮吸收装置上,采用正交试验的设计方法研究不同浓度的氮酮、薄荷醇、冰片联用对双氯芬酸钠在离体裸小鼠背部皮肤上的透皮行为,以累积透过量、渗透速率和滞后时间为药效指标,运用Topsis法评价促透效果。结果:对双氯芬钠的促透作用,氮酮2%、薄荷醇2%、冰片1%联用促透效果最好,其中以氮酮的促透作用最为明显。结论:三种促透剂的联合使用能有效促进双氯芬酸钠的透皮吸收,Topsis法可客观、公正地评价促透剂的促透效果并选出最优方案。

Effect of Using Several Transdermal Enhancers Together on Absorption of Diclofenac Sodium through Skin on Nude Mice in Vitro

Objective: To study the effect of using sevearal transdermal enhancers together on absorption of drugs through skin in vitro.Method:We set up an orthogonal experiment,use diclofenac sodium as drug model,detect the pemeate velocity(P),lag time(Tlag),and transit dose accumulated in 24 hours(Q24) as index of drug action of azone,menthol and camphol using together on skin of back of unde rat on the equipment of percutaneous absorption in vitro,evaluate the contribution of transdermal enhancers by Topsis.Result:Together use of azone 2%,menthol 2% and camphol 1% has the best transdermal enhance effect of the absorption of diclofenac sodium,of which azone has the strongest effect on percutaneous absorption of diclofenac sodium.Conclusion:Using three transdermal enhancers together promotes the percutaneous absorption of diclofenac sodium in vitro effectively.Topsis can evaluate the effect of transdermal enhancers and find the best match objectively.