A new picornavirus isolated from bank voles (Clethrionomys glareolus) |
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Authors: | Niklasson B Kinnunen L Hörnfeldt B Hörling J Benemar C Hedlund K O Matskova L Hyypiä T Winberg G |
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Institution: | Swedish Institute for Infectious Disease Control, Solna, S-171 82, Sweden. bo.niklasson@smi.ki.se |
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Abstract: | A previously unknown picornavirus was isolated from bank voles (Clethrionomys glareolus). Electron microscopy images and sequence data of the prototype isolate, named Ljungan virus, showed that it is a picornavirus. The amino acid sequences of predicted Ljungan virus capsid proteins VP2 and VP3 were closely related to the human pathogen echovirus 22 (approximately 70% similarity). A partial 5' noncoding region sequence of Ljungan virus showed the highest degree of relatedness to cardioviruses. Two additional isolates were serologically and molecularly related to the prototype. |
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