PTEN和Her-2表达与乳腺癌长期预后的关系

目的:探讨PTEN及Her-2在人原发性乳腺癌组织中表达的临床意义及其对术后生存时间的影响。 方法:应用免疫组化法检测81例有15年可靠随访资料的乳腺癌石蜡标本中Her-2和PTEN的表达。采用卡方检验，Kaplan Meier法及Log－rank检验， Cox模型回归分析等方法分析PTEN及Her-2在原发性乳腺癌组织中单独表达及共表达的临床意义。 结果:(1)PTEN表达显著影响乳腺癌患者术后5年和10年的生存率（P<0.01和P<0.05）；PTEN表达与Her-2显著负相关（P<0.01）；(2)PTEN阴性合并Her-2阳性表达患者的5年和10年生存率显著低于PTEN阳性合并Her-2阴性表达的患者；(3)肿瘤大小、术后辅助治疗和PTEN的表达可以作为影响5年生存率有意义的风险因素（P<0.05），而ER、Her-2和PTEN的表达可以作为影响10年生存率有意义的风险因素（P<0.05）。 结论: PTEN与Her-2表达可以影响乳腺癌术后生存率，Her-2和PTEN的表达可以作为分子标记物判断乳腺癌的预后。

Prognostic prediction of PTEN and Her-2 expression in breast cancer

AIM: To study the prognositic value of PTEN and Her-2 expression in primary breast cancer.METHODS: 81 breast cancer specimens with 15 years follow-up were obtained from 1989 to 2004.Immunohistochemical methods were used to detect the expression of PTEN and Her-2 in 81 paraffin-embedded specimens.The correlation between expression of PTEN and clinipathological factors was discussed with the Chi-square test.The survival rate analysis results were calculated with Kaplan-meier method.Long-rank test and Cox model by SPSS 10.0 software.RESULTS:(1) PTEN expression significantly affects 5-year and 10-year survival rate of breast cancer(P<0.01 and P<0.05),and significantly negative correlation with the Her-2 expression was observed.(2) The patients with negative PTEN combined with positive Her-2 expression had worse prognosis.(3) Tumor sizes,postoperative therapy and PTEN expression had significant relation with the 5-year survival rate(P<0.05),and ER,Her2 and PTEN expression had significant relation with the 10-year survival rate(P<0.05).CONCLUSION: PTEN and Her-2 expression significantly affects 5-year and 10-year survival rate in patients with breast cancer,and may be biomarkers and important prognostic factors in breast cancer.