| 内皮素1在急性呼吸窘迫综合征炎症反应中的作用 |
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| 引用本文： | 封珊,王智勇. 内皮素1在急性呼吸窘迫综合征炎症反应中的作用[J]. 国际呼吸杂志, 2008, 28(23): 1468-1472 |
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| 作者姓名： | 封珊 王智勇 |
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| 作者单位： | 河北医科大学第三医院ICU,石家庄,050051 |
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| 摘 要： | 目前认为,炎症反应是急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)发病的重要机制.许多研究证明,内皮素1在ARDS炎症反应中发挥促炎作用.本综述通过回顾内皮素系统的研究进展,阐述内皮素1的炎症作用在ARDS的病理生理学机制、通透性肺水肿及肺动脉高压形成中的作用,及内皮素受体拮抗剂的应用现状.
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| 关 键 词： | 内皮素1 急性呼吸窘迫综合征 炎症反应 病理生理 |
Role of endothelin-1 in inflammation of acute respiratory distress syndrome |
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| FENG Shan,WANG Zhi-yong. Role of endothelin-1 in inflammation of acute respiratory distress syndrome[J]. International Journal of Respiration, 2008, 28(23): 1468-1472 |
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| Authors: | FENG Shan WANG Zhi-yong |
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| Abstract: | Inflammatory reaction may play an important role in the pathogenesy of acute respiratory distress syndrome(ARDS).As a number of studies have proven,the inflammatory effect of endothelin-1(ET-1)has been implicated in the pathophysiology of ARDS.This review will focus on the biologv of ET-1 and its role as a inflammatory mediator in the pathogenesy of ARDS,the formation of pulmonary edema and pulmonary hypertension.And the recent application of endothelin receptor antagonists will be discussed. |
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| Keywords: | Endothelin-1 Acute respiratory distress syndrome Inflammation Pathophysiology |
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