血清甲状腺激素水平对肺心病合并右心衰竭患者的临床意义

目的：研究分析肺心病合并右心衰患者的血清三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)等甲状腺激素检测的临床意义。方法选取本院收治的96例肺心病合并右心衰患者作为观察组，另选50例健康体检对象作为健康组，检测并比较两组人群的甲状腺激素水平并进行比较分析，并依据观察组患者的心功能分级进行分层分析。结果观察组患者的 T3、T4、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平显著的低于健康组患者且差异均具有统计学意义(P <0.05)，观察组和健康组的促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)水平与健康组差异无统计学意义(P >0.05)。心功能Ⅱ级、Ⅲ级患者的 T3、T4、FT3、FT4显著的低于Ⅳ级心功能患者(P <0.05)；观察组心功能Ⅱ级、Ⅲ级、Ⅳ级心功能患者的TSH、TGAb、TPOAb 水平差异无统计学意义(P >0.05)。结论肺心病合并右心衰患者的血清甲状腺激素水平较正常人群发生显著的改变，并且与患者的心功能具有一定的关系。

Clinical significance of serum thyroid hormone in patients with pulmonary heart disease complicated with right heart failure

Objective To study the clinical significance of serum three triiodothyronine (T3) and four triiodothyronine (T4) in patients with pulmonary heart disease combined with heart failure in patients with heart failure,and the clinical significance of thyroid hormone detection.Methods 96 cases of pulmonary heart disease complicated with right heart failure patients selected as observation group,50 cases of healthy subjects were selected as healthy group and were detected and compared between the two groups of populations of thyroid hormone levels and comparative analysis and based on observation of patients heart function classification stratification analysis.Results The levels of T3,T4,FT3 and FT4 in the observation group were significantly lower than those in the healthy group (P < 0.05),and the difference of Thyroglobulin antibody (TGAb) and Thyroid peroxidase antibody (TPOAb) between the observation group and the healthy group showed no significant difference(P >0.05).T4,FT3,FT4 and T3 were significantly lower than that of grade III (P <0.05),and the difference of TPOAb,TGAb and TSH in patients with heart function showed no significant difference (P > 0.05).Conclusions The changes of serum thyroid hormone levels in patients with pulmonary heart disease combined with heart failure were significantly different compared with the normal population,and the heart function of patients with pulmonary heart disease had a certain relationship with the patients with heart failure.