热性惊厥发病机制及干预治疗的研究进展

热性惊厥是一种常见的小儿神经系统惊厥性疾病。临床上分为单纯性热性惊厥及复杂性热性惊厥。目前已在热性惊厥的定义、病因、发病机制、治疗和远期预后等方面进行了广泛而深入的研究，但尚存争议。该文就近年热性惊厥在遗传学、离子通道、免疫学、神经递质机制及治疗、预防对策等方面的研究进展进行综述，旨在提高广大医务人员对该病的正确认识。

Advances in the pathogenesis and treatment of febrile seizures

Febrile seizures ( FS ) is a common convulsive disorder in infants and young children. It is clinically classified into simple febrile seizures(SFS)and complex febrile seizures(CFS). Although intensively investigated,it remains controversial on the etiology,pathogenesis,treatment,long-term prognosis of FS,even the definition itself is still under debate. This paper briefly reviews recent advances on the underlying mechanisms of FS,including involvement of genetic factors,role of ion channels,and immunologic and neurotransmitter dysreg-ulation. We also gathered some new insights on the treatment and prevention of FS,aiming to improve our under-standing of FS.