欣普贝生促宫颈成熟后对阴道分娩、围产儿结局的影响

目的 探讨应用欣普贝生进行促宫颈成熟对阴道分娩的围产儿结局的影响.方法 选取2015年1月至10月成都市妇女儿童中心医院收治的70例宫颈未成熟的足月妊娠孕妇为研究对象,随机分为观察组与对照组,各35例,观察组应用欣普贝生置于阴道促宫颈成熟,对照组直接应用引产素引产,对比两组各产程时间、新生儿结局及产后出血情况.结果 观察组孕妇用药至临产时间、总产程均显著短于对照组(t值分别为9.532、7.674,均P<0.05).观察组引产成功率及自然分娩率均显著高于对照组(χ2值分别为8.915、10.731,均P<0.05).两组围产儿胎内窘迫及新生儿窒息的发生率比较均无显著性差异(χ2值分别为1.312、0.815,均P>0.05),对照组围产儿高胆红素血症的发生率显著高于观察组(χ2=7.431,P<0.05).两组子宫过度刺激、产妇发热、胃肠道不良反应和产后出血发生率比较均无显著性差异(χ2值分别为1.763、0.323、0.219、0.136,均P>0.05).结论 欣普贝生应用于孕妇促宫颈成熟能够显著缩短产程,并能提高引产成功率及阴道分娩率,安全性高,值得临床推广.

Effect of dinoprostone on vaginal delivery and perinatal outcomes after cervical ripening

Objective To investigate the effect of dinoprostone on vaginal delivery and perinatal outcomes in promoting cervical ripening. Methods From January to October in 2015, 70 cases of cervical immature term pregnant women were selected from Chengdu Women and Children's Center Hospital, and they were randomly divided into observation group and control group with 35 cases in each.Dinoprostone was placed in vagina to promote cervical ripening in the observation group, and cases in the control group directly accepted hormone induction abortion.Two groups were compared in labor time, neonatal outcomes and postpartum hemorrhage.Results The interval between use of medicine and labor time, and total labor of the observation group were significantly shorter than those of the control group (t value was 9.532 and 7.674, respectively, both P<0.05).The success rate of induced labor and natural birth of the observation group were significantly higher than those of the control group (t value was 8.915 and 10.731, respectively, both P<0.05).There was no significant difference in the incidence of perinatal fetal distress and neonatal asphyxia between two groups (χ2 value was 1.312 and 0.815, respectively, both P>0.05).The incidence of high blood bilirubin of the control group was significantly higher than that of the observation group (χ2 =7.431,P <0.05).There was no significant difference in uterus overstimulation, maternal fever, gastrointestinal adverse reactions, and the incidence of postpartum hemorrhage between two groups (χ2 value was 1.763, 0.323, 0.219 and 0.136, respectively, all P>0.05) .Conclusion The application of dinoprostone in pregnant women to promote cervical ripening can significantly shorten labor process and improve the success rate of induced labor and vaginal delivery rate with high security.It is worthy of clinical promotion.