降钙素原、C反应蛋白、前清蛋白及白细胞计数在儿童手足口病诊断中的应用价值

目的探讨降钙素原(PCT)、C反应蛋白(CRP)、前清蛋白(PA)、白细胞(WBC)计数在儿童手足口病(HFMD)诊断中的应用价值。方法将209例HFMD患儿按病情分为普通病例组(171例)及重症病例组(38例),另外选择同期30例健康体检儿童纳入对照组,测定3组儿童PCT、CRP、PA及WBC水平,并进行比较。结果普通病例组的PCT、CRP、PA、WBC水平分别为0.16(0.08~0.34)μg/L、11.7(5.0~19.0)mg/L、(142.6±38.4)mg/L、(11.3±4.6)×12~9/L,重症病例组分别为0.26(0.14~0.92)μg/L、18.4(5.3~41.4)mg/L、(125.5±32.9)mg/L、(13.0±5.6)×12~9/L,与对照组相比,差异均有统计学意义(P0.05);重症病例组的PCT、CRP及PA与普通病例组相比,差异有统计学意义(P0.05)。结论 PCT、CRP、PA及WBC可作为HFMD炎性反应参考指标,用于辅助诊断儿童HFMD,PCT及PA可用于病情严重程度的评估。

Application value of procalcitonin,C-reactive protein,prealbumi and white blood cell in children with hand-foot-and-mouth disease

Objective To investigate the application value of procalcitonin (PCT ) ,C-reactive protein (CRP) ,prealbumi (PA ) and white blood cell count (WBC))in children with hand-foot-and-mouth disease (HFMD) .Methods A total of 209 children with HFMD were classified into ordinary group (171 patients) and severe group (38 patients) according to the condition of disease ,an-other 30 healthy children were selected as the control group .The levels of PCT ,CRP ,PA and WBC in the three groups were meas-ured and compared .Results The levels of PCT ,CRP ,PA and WBC of ordinary group were 0 .16(0 .08 - 0 .34)μg/L ,11 .7(5 .0 -19 .0)mg/L ,(142 .6 ± 38 .4)mg /L and (11 .3 ± 4 .6) × 129 /L respectively ,and those of severe group were 0 .26(0 .14 - 0 .92)μg /L , 18 .4(5 .3 - 41 .4) mg /L ,(125 .5 ± 32 .9)mg/L and (13 .0 ± 5 .6) × 129 /L respectively .The PCT ,CRP ,PA and WBC in ordinary group and severe group were significantly different with those in the control group (P < 0 .05) .The PCT ,CRP and PA in severe group had statistical differences compared with those in the ordinary group (P< 0 .05) .Conclusion PCT ,CRP ,PA and WBC could be used as reference indexes of inflammation in HFMD ,and could be used in the diagnosis of HFMD in children ,PCT and PA could be used to evaluate the severity of disease .