脓毒症与线粒体功能障碍 |
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引用本文: | 杨雪.脓毒症与线粒体功能障碍[J].国际儿科学杂志,2016(1):70-73. |
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作者姓名: | 杨雪 |
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作者单位: | 复旦大学附属儿科医院, 上海,201102 |
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摘 要: | 脓毒症为各种病原菌侵入机体后引起的全身炎症反应综合征。脓毒症、严重脓毒症、脓毒症休克、多脏器功能衰竭为疾病的进展过程。线粒体被称为“动力工厂”,为各脏器维持正常功能提供能量。脓毒症时免疫异常、多种炎症因子的激活及释放、细胞内信号传递异常及氧化应激等可引起线粒体功能障碍。最近研究提出,线粒体自噬在线粒体功能障碍中也起着一定作用。该文就脓毒症时引起机体线粒体损伤的机制进行综述。
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关 键 词: | 脓毒症 线粒体损伤 线粒体自噬 |
Sepsis and mitochondrial function damage |
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Abstract: | Sepsis is a complex systemic inflammatory response syndrome caused by invasion of a varie-ty of pathogenic bacteria. The disease spectrum includes sepsis, severe sepsis, septic shock and multiple organ failure. Mitochondria are referred to as “power plants”, providing energy for viscera to maintain normal func-tion. Immune disorders,the activation and release of a series of inflammatory factors,anomalies of intracellular signal transmission and oxidative stress in sepsis can induce mitochondrial dysfunction. Recent research suggests that mitochondrial autophagy also plays a certain role in mitochondrial dysfunction. This article reviews the mechanism of mitochondrial functional damage during the pathogenesis of sepsis. |
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Keywords: | Sepsis Mitochondrial damage Mitochondrial autophagy |
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