甲状腺功能亢进治疗前后呼吸肌功能及血清酶学变化的研究

为了解甲状腺功能亢进对呼吸岂功能的影响，测定了６０例Ｇｒａｖｅｓ病伴甲状腺功能亢进症患者治疗的前甲状腺功能，血清酶，血钾，呼吸肌功能及肺功能，其中后复查２６例，并与２０例正常对照组相比较。结果显示：６０例甲亢患者治疗前Ｔ３，Ｔ４，ＦＴ４明显高于正常，而反映呼吸肌力的指标及吸气肌储血功能明显低于正常组。

Respiratory muscle function and serum enzymology in hyperthyroidism before and after treatment]

To investigate the effect of hyperthyroidism on respiratory muscle function and its possible mechanism, the thyroid function, serum enzymology, serum potassium, pulmonary function and respiratory muscle function were examined in 60 patients with Grave's disease before treatment and 26 patients among them after treatment, and 20 normal subjects as control. T3, T4, and FT4 increased while FVC and PImax, which reflect the respiratory muscle strength, and Pi/PImax, which reflects the reserve capacity of inspiratory muscle, decreased significantly in the 60 patients with Grave's disease, compared with the ones of normal subjects. The comparison of above measurements in the 26 patients between before- and after-treatment showed that respiratory muscle strength increased obviously along with the improvement of throid function. The serum enzymology, potassium and TSH, however, were not abnormal and not changed after treatment. The thyroid functions in 10 patients with hyperthyroid heart disease were not different, compared with the ones of other 50 patients without hyperthyroid heart disease, but their respiratory muscle strength was significantly lower than the ones of latter. The above results suggested that hyperthyroidism could lead to significant decrease of respiratory muscle strength and its reserve capacity, whereas treatment for hyperthyroidism would improve respiratory muscle function, so the measurement of respiratory muscle function in hyperthyroidism cases might be useful in prediction of hyperthyroid heart disease.