老年人与青年人染色体脆性位点的比较

作者研究了４５例老年人和２９例青年人外周血淋巴细胞在ＦＵＤＲ和咖啡因诱导下，外周血淋巴细胞染色体的畸变及脆性位占的表达。结果：１．老年组染色体畸变率为２４．７５％，青年组为４．２２％，两者差异显著。２．老年组脆性全点表达率为４５．９３％，青年组为２３．０２％，明显低于老年组；３．染色体断裂点与脆性位点符合率老年组为７９．９８％，青年组为９２％，说明脆性位点与染色体畸变密切相关。

A comparison of chromosome fragile sites in elderly and young people]

In this comparative study, the authors investigated the chromosome aberrations and expression of fragile sites in the lymphocytes which were collected from 45 elderly people and 29 young people and were cultured with FUDR for 24 hours. The results showed that the aberration rate was 24.75% for elderly people, but 4.22% for young people (P < 0.01): that the expression of fragile sites was 45.94% for elderly peoples, but 23.02% for young people (P < 0.01): and that the relation of aberrations with fragile sites was 79.98% for elderly people, and 92% for young people. These findings suggest that chromosome aberration is in close association with fragile site.