肝母细胞瘤的临床病理与免疫组化研究

为探讨肝母细胞瘤各组织类型的免疫表达和预后的关系，作者对２０例肝母细胞瘤进行了临床病理分析，其中１８例还作了７种标记的免疫组化染色。结果细胞角蛋白、甲胎蛋白、Ｓ－１００蛋白和波形蛋白在肿瘤上皮细胞浆的表达分别为１４例、１０例、９例和４例；细胞核中癌胚抗原、Ｐ５３和Ｐ１６蛋白的表达分别是１１例、９例和７例。此外，还有１例肿瘤的间叶成分同时出现Ｐ１６蛋白、波形蛋白、细胞角蛋白表达。由此提示不同组织学类

Clinicopathological and immunohistochemical study of hepatoblastoma]

To investigate the relationship between immunoreaction of histologic subtype and prognosis, this paper analysed the clinicopathological data from 20 cases of hepatoblastoma. Immunohistochemical staining was performed in 18 cases. The results showed that cytopolasmic postivities of epithlial tumor cells were observed by CK, AFP, S-100 protein and vimentin in 14, 10, 9 and 4 cases respectively. Positive staining for CEA was seen in the nuclei of epithelial tumor cells in 11 cases. Nuclear P53 protein staining was found in 9 cases. Nuclear and cytoplasmic postivities of P16 protein were observed in 7 cases. S-100 protein, vimentin, CK and P16 protein were detected in mesenchymal component in 1 case. This study suggested that immunoreactions of hepatoblastomas were different in histologic subtypes. The expression may correlate with the neoplastic differentiation and prognosis.