壳聚糖硫酸盐催化合成环扁桃酯 |
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引用本文: | 臧皓,李晓东,孙佳明,孙道磊,张辉.壳聚糖硫酸盐催化合成环扁桃酯[J].中国医药工业杂志,2010,41(3). |
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作者姓名: | 臧皓 李晓东 孙佳明 孙道磊 张辉 |
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作者单位: | 1. 长春中医药大学中医药与生物工程研发中心,吉林长春,130117 2. 吉林省博大制药有限责任公司,吉林辽源,136200 |
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摘 要: | 以扁桃酸和3,3,5-三甲基环己醇为原料,甲苯为溶剂,壳聚糖硫酸盐为催化剂制得环扁桃酯,最佳反应条件为:扁桃酸、3,3,5-三甲基环己醇、甲苯和壳聚糖硫酸盐投料比为1:1:2.86:9.1(mol:mol:mol:g),反应时间8h,收率约84%.
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关 键 词: | 环扁桃酯 周围血管扩张药 壳聚糖硫酸盐 合成 |
Synthesis of Cyclandelate with Chitosan Sulfate as Catalyst |
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Authors: | ZANG Hao LI Xiaodong SUN Jiaming SUN Daolei ZHANG Hui |
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Abstract: | Cyclandelate was synthesized from mandelic acid and 3,3,5-trimethyl cyclohexanol by esterification in toluene with chitosan sulfate as catalyst in 84.3% yield, the optimal ratio of mandelic acid, 3,3,5-trimethyl cyclohexanol, toluene and chitosan sulfate was 1 : 1: 2.86 : 9.1 (mol : mol : mol: g). |
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Keywords: | cyclandelate peripheral vasodilator chitosan sulfate synthesis |
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