Eotaxin和Eotaxin-2在鼻息肉病和鼻息肉组织中的表达及意义

目的：了解嗜酸粒细胞（EOs）趋化因子Eotaxin、Eotaxin-2在人鼻息肉病和鼻息肉组织中的表达情况，探讨鼻息肉与鼻息肉病发病机制上的异同。方法：采用免疫组织化学方法（SP法）检测15例鼻息肉病患者（鼻息肉病组）、13例鼻息肉患者（鼻息肉组）的息肉组织和8例行鼻中隔偏曲矫正术患者的中鼻甲组织（对照组）中Eotaxin和Eotaxin-2的表达。结果：Eotaxin-2在对照组、鼻息肉组和鼻息肉病组3组间呈递增表达，且每2组间比较均差异有统计学意义（均P〈0．05）；Eotaxin在鼻息肉病和鼻息肉组中的表达均显著高于对照组（均P〈0．05），而在鼻息肉病组与鼻息肉组间表达差异无统计学意义。结论：Eotaxin和Eotaxin-2可能均参与了鼻息肉病与鼻息肉的炎症反应过程，Eotaxin-2在鼻息肉病和鼻息肉组织之间的不同表达提示它可能是鼻息肉病与鼻息肉发病机制不同的重要原因之一。

Expression and significance of Eotaxin and Eotaxin-2 in nasal polyposis and nasal polyp tissue

Objective:To study the expression of Eotaxin and Eotaxin-2 in nasal polyposis and nasal polyp and explore the different mechanism between polyposis and polyp.Method:Fifteen cases of nasal polyposis,thirteen cases of polyp and eight cases of normal middle turbinate were studied with immunohistochemical SP method to detect the expression of Eotaxin and Eotaxin-2.Result:There were significant differences between either two groups about the expression of Eotaxin-2(P<0.05).The expression of Eotaxin in nasal polyosis and polyp were dramatically higher than in controls(P<0.05),the expression of Eotaxin between nasal polyosis and polyp was no remarkable difference(P>0.05).Conclusion:Both of Eotaxin and Eotaxin-2 likely play key roles in the inflammatory reaction process of nasal polyosis and polyp.The different expression of Eotaxin-2 between nasal polyosis and polyp demostrates it may be one of the main causes in the different mechanism of the two diseases.