东莞厚街镇小儿先天性心脏病危险因素分析

目的了解广东省东莞市厚街镇先天性心脏病的发病因素,掌握其流行病学特征,以便有针对性地采取预防措施,降低先天性心脏病的发生。方法分析东莞厚街镇内1岁以下先天性心脏缺陷患儿138例的监测资料,对138例先天性心脏病患儿与138例对照组小儿的母亲进行生活行为、工作环境、饮食习惯等进行问卷调查并作对比分析。结果病例组孕母孕早期3个月内病毒感染比例及接触化学试剂比例均明显高于对照组,差异有统计学意义(10.9%vs.3.6%,P0.05;10.1%vs.0%,P0.01)。结论厚街镇小儿先天性心脏病发生的有关危险因素包括孕早期接触化学制剂及病毒感染。厚街镇流动人口的产前保健宣教工作有待加强,孕妇应远离有害环境。

Risk factors for congenital heart disease in Houjie Town of Dongguan Guangdong Province

Objectives To get the message of epidemiological characteristics and risk factors of congenital heart disease （ CHD ） in neonate and children in Houjie Town in Dongguan of Guangdong Province and to improve prevention of CHD. Methods We analyzed the monitoring data of 138 neonate and children （aged〈1 year）with CHD （CHD group） from Guangdong CHD monitoring system in Houjie.According to the 1：1 matched to CHD group principle,we selected 138 children aged〈1 year as control group. Life style, work environment and dietary habit of all the mothers of CHD group and control group were interviewed and compared. Results The rates of viral infection and chemical agent contacting in the first 3 months of pregnancy in mothers of CHD group were significantly higher than those in mothers of control group （10.9% vs.3.6%,P〈0.05; 10.1% vs.0%,P〈0.01）. Conclusions Risk factors for congenital heart disease in Houjie Town of Dongguan Guangdong Province include viral infection and chemical agent contacting in the early pregnancy. Heahhcare educuction in pregnancy should be improved in Houjie Town and pregnancy women shoud keep away from hostile environment.