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| 乌市水磨沟区糖尿病高危人群HOMA-IS与血清25-(OH)D_3相关 | |
| 引用本文： | 安娜,张丽,尹琦,樊勇,刘俊娟,王军,权丽,朱筠. 乌市水磨沟区糖尿病高危人群HOMA-IS与血清25-(OH)D_3相关[J]. 中华内分泌代谢杂志, 2009, 25(6). DOI: 10.3760/cma.j.issn.1000-6699.2009.06.013 |
| 作者姓名： | 安娜 张丽 尹琦 樊勇 刘俊娟 王军 权丽 朱筠 |
| 作者单位： | 1. 新疆医科大学第五附属医院内分泌科 2. 新疆医科大学第一附属医院内分泌科,乌鲁木齐,830000 3. 新疆乌鲁木齐市六道湾社区卫牛服务中心 |
| 基金项目： | 新疆自然科学基金资助项目，新疆医科大学创新基金 |
| 摘 要： | 569例受试者(糖尿病高危人群)按稳态模型评估的β细胞功能指数(HOMA-IS)中位数,分为ISI组(HOMA-IS>104.83)和IS2组(HOMA-IS≤104.83).IS2组的血清25-(OH)D_3、空腹胰岛素、体重指数、腰围和总胆固醇明显下降,空腹血糖和服糖后2 h血糖明显上升.相关分析显示,HOMA-IS与体重指数、腰围、总胆固醇、血清25-(OH)D_3均呈正相关关系(均P<0.05),HOMA-IS与服糖后2 h 血糖呈负相关关系(P<0.05).提示在乌鲁木齐市水磨沟区糖尿病高危人群中,血清维生素D水平降低可能与胰岛β细胞功能损伤相关. |
| 关 键 词： | 糖尿病 胰岛β细胞功能 25-(OH)维生素D_3 |
HOMA-IS correlates with serum 25-(OH)D_3 in the people with high risk to diabetes mellitus in Shuimogou District,Urumqi |
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| Abstract: | Five-hundred and sixty-nine subjects with high risk to diabetic mellitus were assigned into two groups according to the median of homeostasis model assessment for insulin sensitivity(HOMA-IS):ISl group (HOMA-IS>104.83)and IS2 group(HOMA-IS≤104.83).Serum 25-(OH)D_3,fastinginsulin,body mass index (BMI),waist circumference(WC),and total cholesterol(TC)were decreased,but fasting and postprandial blood glucose were increased in IS2 group.Positive correlations of HOMA-IS with serum 25-(OH)D_3,BMI,WC,and TC,while negative correlation with 2hPG were found(all P<0.05).It suggested that low level of sel'um vitamin D may be related to the islet β-cell function in the people with high risk of diabetic mellitus in Shuimogou District of Urumqi. |
| Keywords: | Diabetic mellitus Islet β-cell function 25-(OH)vitamin D_3 |
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