Interleukins,laminin and epstein - barr virus latent membrane protein 1 (EBV LMP1) Promote metastatic phenotype in nasopharyngeal carcinoma |
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| Authors: | Michelle MS Chew Sook-Yee Gan Alan SB Khoo Eng-Lai Tan |
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| Affiliation: | 1.Department of Research and Postgraduate Studies,International Medical University,Kuala Lumpur,Malaysia;2.Department of Pharmacy and Health Sciences,International Medical University,Kuala Lumpur,Malaysia;3.Cancer Research Centre, Institute for Medical Research, Jalan Pahang,Kuala Lumpur,Malaysia |
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| Abstract: | Background Nasopharyngeal carcinoma (NPC) is a type of neoplasm that is highly prevalent in East Asia and Africa with Epstein-Barr virus (EBV), genetic, and dietary factors implicated as possible aetiologic factors. Previous studies suggested the association of certain cytokines with the invasion and metastatic properties of NPC. The present study examined the roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6), interleukin-10 (IL-10), transforming growth factor-beta 1 (TGF-β1) and laminin in the regulation of matrix-metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) in NPC. The effects of these factors on bmi-1, an oncogene, and ngx6, a tumour suppressor gene, were also investigated. |
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