| 立体控制合成外向—1—乙炔基—3—二苯叔丁硅氧基双环[3.1.0]已烷 |
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| 摘 要： |
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| 关 键 词： | 乙炔基－二苯叔丁硅氧基双环已烷 A环合成子 合成 立体控制 |
The stereocontrolled synthesis of 1-acetylenyl-3-tert-butyldiphenylsilyloxy-exo-bicyclo [3. 1. 0] hexane] |
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| Authors: | Y Wu M Guan H Zhu |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, WCUMS, Chengdu 610041, China. |
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| Abstract: | OBJECTIVE: In order to find out more effective method for the synthesis of the A-ring synthon, (-)-1-acetylenyl-3-tert-butyldiphenylsily-loxy-exo-bicyclo 3. 1. 0] hexane (3), for 19-nor-1 alpha, 25-dihydroxyvitamin D3(2)with commercial value. METHODS: We synthesized the A-ring synthon (+/-)(3) via nine steps with good yield starting from 3-cyclopentenyl alcohol(4). RESULTS: The spectral data of compound (+/-)(3) is the same as the spectral data of (-)(3) which reported preciously by us. CONCLUSION: The method is an effective method for synthesis of the A-ring synthon (3). |
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