缬沙坦治疗慢性肾功能衰竭高血压26例

目的观察缬沙坦对慢性肾功能衰竭高血压患者的疗效.方法慢性肾功能衰竭高血压患者47例,随机分为治疗组26例,给予缬沙坦片80 mg,qd,po;对照组21例,给予非洛地平片5 mg,qd,po.基础治疗相同,疗程均为4周.结果治疗组有效率76.9%,对照组有效率57.1%,治疗组血压下降优于对照组(P＜0.05),治疗组24 h尿蛋白定量降低而对照组无明显变化,两组对内生肌酐清除率均无影响.结论缬沙坦可有效降低慢性肾功能衰竭高血压患者的血压,减轻蛋白尿,延缓肾功能不全的发展.口服耐受性好,不良反应少.

The Effect of Valsartan in the Treatment of 26 Patients with Hypertension Complicated by Chronic Renal Failure

Objective:To investigate the therapeutic effect of valsartan in the treatment of hypertension complicated by chronic renal failure. Methods:47 patients with hypertension complicated by chronic renal failure were randomly divided into 2 groups, the treatment group ( n =26) and control group ( n =21). On the basis of routine treatment, patients of the treatment group were given each 80mg of valsartan q.d., PO, while those of the control group were given each 5 mg of felodipine q.d. PO. The course of treatment in both groups lasted 4 weeks. Results:The effective rates were 76.9% and 57.1% ( P <0.05) in the treatment group and control group, respectively. The arterial blood pressure in patients of the treatment group dropped to a prominently lower level than that of the control group ( P <0.05). The amount of urinary protein was reduced in patients of the treatment group but not of the control group. The difference in Ccr between the two groups was insignificant. Conclusion:Valsartan was shown to be effective in lowering blood pressure, alleviating proteinuria and retarding the progress of renal insufficiency in patients with hypertension complicated by chronic renal failure. Oral administration of the drug was well tolerated and adverse reactions were mild.