聚乳酸膜和脱钙冻干胚胎骨促进骨修复的比较研究

目的 比较聚乳酸（ＰＬＡ）膜和脱钙冻干胚胎骨（ＦｅｔａｌＢｏｎｅ，ＦＢ）促进骨修复的能力，方法 在１２只日本大耳白兔双侧下颌骨下缘中份作方块切除形成缺损，一侧缺损植入ＦＢ，另一侧缺损表面覆盖ＰＬＡ膜，术后４，８，１２周分期处死动物，下颌骨标示行放射学和组织学观察，结果 两种材料均能有效修复骨缺损，ＦＢ植入４Ｗ后术区内有大量新骨形成，术后８Ｗ缺损内骨形成活跃程度和骨形成量均高于ＰＬＡ膜侧，结论 ＦＢ

A Comparative Study of Promoting Bone Healing by PLA Membrane and Demineralized Freeze-Dried Fetal Bone

Objective To compare the effection of PLA membrane and demineralized freeze-dried fetal bone on promoting bone formation. Materials and Methods Bilateral mandibular defects were created in twelve adult rabbits.Left defects were filled with FB,and the right defects were covered by PLA membranes.Animals were sacrified at 4,8,12 weeks after operation.The mandible specimens were assessed by radiograph and light macroscopy. Results Newly-formed bone in left bone defect was greater than those in right defect at each stage. Conclusion This study indicates that FB is the more preferable material for repairing mandibular defect.