18F-氟脱氧葡萄糖以外新型PET肿瘤显像剂

^18F-氟脱氧葡萄糖PET虽是一种非常敏感的技术，但其特异性不高，有一定的局限性。因此，其他一些用于研究氨基酸摄取、蛋白质合成、DNA合成、细胞增殖、三羧酸循环中其他底物的代谢改变、肿瘤乏氧性、免疫活性和受体的示踪剂有望成为新的肿瘤显像剂。这些药物主要包括，^18F-、^11C等标记的用于PET肿瘤显像的短半衰期放射l生药物。

New type PET imaging agent excluding 18F-fluorodeoxyglucose in oncology

18F-fluorodeoxyglucose PET is a very sensitive technology,yet it still has limitation such as low specificity. In this way,tracers used to study amino acid uptake,protein synthesis,DNA synthesis,cell proliferation,changes of other substrates of tricarboxylic aciol cycle metabolism,tumor hypoxia,immunological activity and receptor are expected to be new tumor imaging agent. The study and possible use of short half-life radiopharmaceuticals(excluding FDG) in oncology with positron emission tomography are reviewed in this article,those that include 18F and 11C labeled compounds.