| 广州地区汉族人群和白血病患者Rb基因P68RS2.0区的遗传多态性 |
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| 引用本文： | 舒青,曾瑞萍.广州地区汉族人群和白血病患者Rb基因P68RS2.0区的遗传多态性[J].中华医学遗传学杂志,1996,13(2):79-81. |
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| 作者姓名： | 舒青 曾瑞萍 |
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| 作者单位： | 第四军医大学生物教研室，中山医科大学遗传学教研室 |
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| 摘 要： | 为了解Ｒｂ基因在正常人群和白血病患者中的遗传多态性，作者采用３２Ｐ－标记的Ｒｂ基因Ｐ６８ＲＳ２．０探针分别与４种限制性内切酶消化的广州地区汉族人群和白血病患者ＤＮＡ进行了分子杂交，发现一个新的多态位点：正常人ＥｃｏＲ１３．２ｋｂ和３．４ｋｂ，等位基因频率分别为０．７４和０．２６，杂合子频率为０．３７；白血病患者ＥｃｏＲⅠ３．２ｋｂ和３．４ｋｂ，等位基因频率分别为０．８４和０．１６，杂合子频率为０．２４．为白血病的病因学研究提供了资料。
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| 关 键 词： | 汉族，白血病，Rb基因，多态现象（遗传学） |
ALLELE TYPES AND GENETIC GENETIC ANALYSIS OF Rb p68RS2.0 LOCUS IN HAN POPULATION OF GUANGZHOU AND LEUKEMIA |
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| Shu Qing,Zeng Ruiping,Hu Bing,et al..ALLELE TYPES AND GENETIC GENETIC ANALYSIS OF Rb p68RS2.0 LOCUS IN HAN POPULATION OF GUANGZHOU AND LEUKEMIA[J].Chinese Journal of Medical Genetics,1996,13(2):79-81. |
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| Authors: | Shu Qing Zeng Ruiping Hu Bing |
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| Abstract: | A restriction fragment length polymorphism(RFLP) at the human Rb p 68RS2.0 Locus has been detected in a Han population of Guangzhou and a group of leukemia patients by Southern hybridization using 32P-labeled Rb probe.The new polymorphism is generated by the existence of two alleles,3.2kb and 3.4kb.The two alleles were observed with frequencies of 0.74 and 0.26 in Han nationality,and 0.84 and 0.16 in patients with leukemia,respectively;however,there was no statistical difference between the Hans and leukemic patients. |
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| Keywords: | Han nationality Leukemia Rb gene Polymorphism(Genetics) |
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