Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA |
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| Authors: | Maeda Tetsuya Nagata Ken Yoshida Yasuji Kannari Kazuya |
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| Institution: | Department of Neurology, Research Institute for Brain and Blood Vessels, Akita, Japan. maeda@akita-noken.go.jp |
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| Abstract: | The aim of this study was to determine whether raphe-striatal serotonergic neurons of adult rats with extensive nigro-striatal dopaminergic denervation are induced by injection of exogenous L-DOPA to contain dopamine. Double-labeling immunofluorescence study was conducted. In the lesioned striatum of rats that received L-DOPA, serotonergic hyperinnervation was observed, and dopamine was detected in serotonergic varicose fibers. These findings suggest that striatal serotonergic hyperinnervation can compensate for the lost function of dopaminergic neurons. |
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