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| 胃癌患者叶酸代谢通路相关基因的多态性与卡培他滨联合紫杉醇化疗后生存期的关系 | |
| 引用本文： | 郑磊贞,章莉,陈思宇,龚继芳,顾建春,李小平,孙晶,焦晓栋,王杰军.胃癌患者叶酸代谢通路相关基因的多态性与卡培他滨联合紫杉醇化疗后生存期的关系[J].肿瘤,2011,31(5):442-447. |
| 作者姓名： | 郑磊贞 章莉 陈思宇 龚继芳 顾建春 李小平 孙晶 焦晓栋 王杰军 |
| 作者单位： | 1. 上海交通大学医学院附属新华医院肿瘤科,上海,200092 2. 北京肿瘤医院消化内科,北京,100142 3. 第二军医大学附属长征医院肿瘤科,上海,200003 |
| 基金项目： | 上海市里生局科研课题计划项目 |
| 摘 要： | 目的:研究胃癌患者的叶酸代谢通路相关基因和肿瘤相关候选基因的多态性与卡培他滨联合紫杉醇化疗后生存期的关系。方法:选取经病理学确诊的胃癌患者93例,采用卡培他滨联合紫杉醇为主的方案进行化疗。以TaqMan-MGB探针方法进行基因分型,包括肿瘤坏死因子(tumor necrosis factor,TNF)A308G(rs1800629)、亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)C677T(rs1801131)及A1298C(rs1801133)、甲硫氨酸合成酶(methionine synthase,MS或MTR)A2756G(rs1805087)和甲硫氨酸合成还原酶(methionine synthase reductase,MTRR)A66G(rs1801394)基因的分型。比较不同基因型患者在化疗后的中位生存时间(median survival time,MST),以及各种因素对其预后的影响。结果:中位随访时间为29.6个月,93例患者的MST为34.93个月。MTHFR A1298C中携带CA基因型胃癌患者的MST为47.50个月,CC基因型患者的MST为22.91个月;经log-rank检验发现,MTHFR1298C/A基因多态性与患者生存期有边际显著性关系(χ2=3.447,P=0.062)。其他基因型多态性与胃癌患者的生存期无显著相关性。COX回归分析显示,性别、酗酒和手术是胃癌患者化疗后预后的主要影响因素。结论:检测MTHFR1298C/A位点基因多态性可在一定程度上预测卡培他滨联合紫杉醇化疗后胃癌患者的生存情况。 |
| 关 键 词： | 胃肿瘤 5 10-亚甲基四氢叶酸还原酶 多态现象 单核苷酸 抗肿瘤联合化疗方案 预后 紫杉醇 卡培他滨 |
Relationship between polymorhisms of related genes in the folic acid metabolic pathway and the survival of gastric cancer patients treated with capecitabine combined with paclitaxel |
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| ZHENG Lei-zhen,ZHANG Li,CHEN Si-yu,GONG ji-fang,GU Jian-chun,LI Xiao-ping,SUN Jing,JIAO Xiao-dong,WANG Jie-jun.Relationship between polymorhisms of related genes in the folic acid metabolic pathway and the survival of gastric cancer patients treated with capecitabine combined with paclitaxel[J].Tumor,2011,31(5):442-447. | |
| Authors: | ZHENG Lei-zhen ZHANG Li CHEN Si-yu GONG ji-fang GU Jian-chun LI Xiao-ping SUN Jing JIAO Xiao-dong WANG Jie-jun |
| Institution: | ZHENG Lei-zhen1,ZHANG Li1,CHEN Si-yu1,GONG Ji-fang2,GU Jian-chun1,LI Xiao-ping1,SUN Jing1,JIAO Xiao-dong3,WANG Jie-jun3 1.Department of Oncology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China,2.Department of Gastroenterology,Beijing Cancer Hospital,Beijing 100142,3.Department of Oncology,Shanghai Changzheng Hospital,Second Military Medical University,Shanghai 200003 |
| Abstract: | Objective:To investigate the association of polymorphisms of related genes in folic acid metabolic pathway and the tumor candidate genes with the survival of gastric cancer patients treated with capecitabine combined with paclitaxel.Methods:Ninety-three patients with pathological diagnosis of gastric cancer were treated with capecitabine plus paclitaxel-based chemotherapy.The gene polymorphisms of tumor necrosis factor(TNF) A308G(rs1800629),methylenetetrahydrofolate reductase(MTHFR) C677T(rs1801131) and A12... |
| Keywords: | Stomach neoplasms 5 10-Methylenetetrahydrofolate reductase Polymorphism single nucleotide Antineoplastic combined chemotherapy protocols Prognosis Paclitaxel Capecitabine |
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