胃癌、大肠癌手术患者42例腹腔灌注化疗与静脉化疗对比分析

目的:探讨胃癌、大肠癌手术患者腹腔灌注化疗与静脉化疗的临床疗效,以提高患者的治愈率、生存率。方法:将42例胃癌、大肠癌患者随机分为腹腔灌注化疗组(IPC组)与静脉化疗组(IVC组),采用MMC、5-FU的方案进行化疗,并比较:1两组术前化疗后腹腔游离癌细胞阴转率;2白细胞术前、术后化疗后的变化;3术后血清可溶性白细胞介素-2受体(SIL-R)的浓度比较;4恶心、呕吐、乏力、脱发等不良反应。结果:1术前腹腔游离癌细胞阳性者,IPC组14例,IVC组8例,经术前化疗后手术,开腹时IPC组10例转为阴性,而IVC组8例仍为阳性。两组比较有显著性差异(P<0.05);2术后2周外周血白细胞下降,腹腔灌注化疗组较静脉化疗组轻微,两组比较有显著性差异(P<0.05);3 IPC组术后10d左右血清SIL-2R水平低于术前(P<0.01),IVC组血清vSIL-2R水平低于术前(P<0.05);4恶心等消化道反应IPC组3例,IVC组13例,乏力、脱发等反应严重的患者IPC组3例,IVC组7例。结论:腹腔灌注化疗能直接杀灭腹腔游离癌细胞,并抑制腹腔内不能用肉眼发现的微小病灶,副作用少,可提高癌症手术患者的治愈率及生存率。

42 patients with colorectal cancer,abdominal surgery patients with venous infusion chemoembolization comparative analysis of chemotherapy

Objective： Through the analysis and comparison of stomach,colorectal surgery patients with venous infusion chemoembolization celiac,find out the most conducive to chemotherapy treatment,in order to enhance the survival rate of the patients.Methods：42 patients with colorectal cancer were randomly divided into,abdominal perfusion chemotherapy group （IPC） and venous chemotherapy group（IVC）,5-its MMC,chemotherapy.Compared：①Two groups of preoperative chemotherapy retroperitoneal free cancer cells turn Yin;② preoperative and postoperative chemotherapy leukocytes after changes;③Postoperative serum soluble interleukin-2 receptor（SIL-R） concentrations;④ Nausea,vomiting,fatigue,adverse reactions such as hair loss.Results ：①Preoperative celiac free cancer group,the IPC positive 14 cases,8 cases of IVC group.After surgery,chemotherapy through preoperative open when the 10 cases into negative IPC group,8 cases of IVC was still positive.There were significant differences between two groups（P0.05）.②After two weeks,peripheral white abdominal perfusion chemotherapy group venous chemotherapy group,there was significant difference between two groups（P0.05）;③The IPC group of postoperative serum SIL-about 10 days before 2R levels below（P0.01）,IVC serum level below the preoperative vSIL 2R（P0.05）;④Nausea and gastrointestinal reaction IPC group（3 cases）,13 cases of IVC group,fatigue,loss of patients with severe reactions such as IPC group（3 cases）,7 cases of IVC group.Conclusion ：Chemotherapy can kill abdominal perfusion abdominal cancer cells,and inhibit free intra-abdominal cannot find tiny lesions with the naked eye,few side-effects,can increase the cure of cancer patients,it is worth popularizing and survival.