| 遗忘型轻度认知功能障碍患者的内嗅皮层形态学与功能变化的研究 |
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| 引用本文： | 李旭东,焦劲松,Itsuki Jibiki.遗忘型轻度认知功能障碍患者的内嗅皮层形态学与功能变化的研究[J].中日友好医院学报,2011,25(3):134-137. |
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| 作者姓名： | 李旭东 焦劲松 Itsuki Jibiki |
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| 作者单位： | 1. 中日友好医院神经内科,北京,100029
2. 金泽医科大学神经精神科,日本920-0293;长久会加贺精神医院,日本922-0831 |
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| 摘 要： | 目的：探讨遗忘型轻度认知功能障碍（aMCI）患者内嗅皮层的形态学改变和相关功能变化的关系。方法：16例遗忘型轻度认知功能障碍患者入选。认知功能通过长谷川痴呆量表修订版（HDS-R）评价。通过基于体素的阿尔茨海默病特异性局部分析系统（VSRAD）的Z评分来评价内嗅皮层的萎缩程度。同时利用单光子发射计算机断层显像（SPECT）的FineSRT技术定量分析各个相关脑区局部脑血流（rCBF）的绝对值。结果：VSRAD的Z评分与年龄呈正相关,与双侧海马、杏仁核、丘脑、右侧海马旁回rCBF的绝对值均显著负相关（均P〈0.05）。此外,Z评分与左侧海马旁回、双侧扣带回中、后部rCBF的绝对值也存在一定程度的负相关趋势。结论：在aMCI患者中,内嗅皮层萎缩与海马相关结构、丘脑、扣带回rCBF变化存在明显的功能联系。这种联系可能与解剖和生理学的网络有关。
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| 关 键 词： | 轻度认知功能障碍 内嗅皮层 基于体素的形态学测量 单光子发射计算机断层显像 |
Morphological and functional changes of the entorhinal cortex in patients with amnestic mild cognitive impairment |
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| LI Xu-dong,JIAO Jin-song,Itsuki Jibiki.Morphological and functional changes of the entorhinal cortex in patients with amnestic mild cognitive impairment[J].Journal of China-Japan Friendship Hospital,2011,25(3):134-137. |
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| Authors: | LI Xu-dong JIAO Jin-song Itsuki Jibiki |
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| Institution: | LI Xu-dong,JIAO Jin-song,JIBIKI Itsuki,et al Department of Neurology,China-Japan Friendship Hospital,Beijing 100029,China |
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| Abstract: | Objective:To investigate the relationships between morphological and functional changes of the entorhinal cortex in patients with amnestic mild cognitive impairment(aMCI).Methods:Sixteen aMCI patients were enrolled,whose cognitive function were evaluated by revised version of Hasegawa's Dementia Scale(HDS-R).Z scores of voxel-based specific regional analysis system for Alzheimer's disease(VSRAD)were determined to assess the degree of atrophy of the entorhinal cortex.Single-photon emission computed tomograph... |
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| Keywords: | mild cognitive impairment entorhinal cortex voxel-based morphometry single-photon emission computed tomography |
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