Lesions in donor kidneys: nature, incidence, and influence on graft function |
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Authors: | J-P Cosyns Jacques Malaise Geneviève Hanique Michel Mourad Alessandra Baldi Rose-Marie Goebbels Jean-Paul Squifflet |
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Institution: | (1) Department of Pathology, University of Louvain Medical School, Cliniques Universitaires St-Luc, 10 Av. Hippocrate, B-1200 Brussels, Belgium Fax: + 32 2 764 8924 e-mail: Cosyns@anps.ucl.ac.be, BE;(2) Department of Renal and Pancreatic Transplantation, University of Louvain Medical School, Cliniques Universitaires St-Luc, 10 Av. Hippocrate, B-1200 Brussels, Belgium, BE |
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Abstract: | The aim of this study was to assess the influence of kidney-donor transmitted pathology on graft function. Light and immunofluorescent
microscopic findings from a surgical biopsy taken prior to transplantation from 114 cadaveric kidney donors were analyzed.
Moderate to severe mesangial IgA deposits were considered consistent with IgA nephropathy. Pathological abnormalities were
correlated together with donor age, number of mismatches, and type of immunosuppression by multivariate statistical analysis
with the serum creatinine values from patients who experienced no acute rejection at 1 year. Serum creatinine values (n = 52) were not correlated with either nonspecific light microscopic lesions or immunofluorescent deposits found in the majority
of kidney donors or with changes consistent with IgA nephropathy observed in 9 % of the cases. There was, however, a correlation
with donor age, which was also correlated with the extent of chronic lesions (P < 0.001).
Received: 5 March 1997 Received after revision: 8 July 1997 Accepted: 21 August 1997 |
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Keywords: | IgA nephropathy kidney transplantation biopsy |
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