Scleraxis和Tenomodulin在肌腱发育成熟中的作用

肌腱是连接肌肉和骨骼系统的的致密结缔组织.目前,临床上肌腱损伤的治疗尚无很好的方法,应用组织工程化技术构建肌腱进行修复为肌腱损伤的治疗提供了良好的前景.了解肌腱的发育成熟过程对组织工程化肌腱构建是相当重要的.Scleraxis和Tenomodulin是肌腱和韧带相对特异的分子标志,在肌腱发育成熟中起了重要作用.就Scleraxis和Tenomodulin的分子结构、在肌腱发育成熟中的作用和其调控予以综述,以加深对肌腱发育过程的认识.

The role of Scleraxis and Tenomodulin in tendon development

Tendons are dense connective tissues that mediate the attachment of the muscle system to the skeletal system. While the methods for clinical tendon repair remain less satisfactory, tissue engineering may pro- vide promising future. Therefore, understanding the natural tendon development process is important for tendon en- gineering. Scleraxis and Tenomodulin are relatively specific molecule makers for tendon and ligment and play im- portant roles in the tendon development. This article gives review of the molecular structure, the expression regula- tion, and the roles of Scleraxis and Tenomodulin in tendon development, in order to better understand the process of tendon development.