| 枇杷叶原料安全性评价 |
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| 引用本文： | 易传祝,胡余明,陈炜林,周月婵,聂焱. 枇杷叶原料安全性评价[J]. 现代预防医学, 2010, 37(5) |
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| 作者姓名： | 易传祝 胡余明 陈炜林 周月婵 聂焱 |
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| 作者单位： | 湖南省疾病预防控制中心,长沙,410005 |
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| 摘 要： | [目的]研究枇杷叶原料的急性毒性、遗传毒性、亚慢性毒性。[方法]采用最大耐受量试验、Ames实验、骨髓细胞微核试验、小鼠精子畸形试验、90d喂养试验进行检测评价。[结果]枇杷叶原料对雌、雄昆明种小鼠的最大耐受剂量(MTD)均大于10.0g/kg·bw,3项遗传毒性试验(Ames试验、骨髓细胞微核试验、小鼠精子畸形试验)结果均为阴性,90d喂养试验受试动物各项生理指标无异常。[结论]枇杷叶原料属无毒级,无遗传毒性,最大未观察到有害作用剂量大于6.4g/kg·bw。
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| 关 键 词： | 枇把叶 急性毒性 遗传毒性 亚慢性毒性 |
SAFETY ASSESSMENT OF LOQUAT LEAF(ERIOBOTRYA JAPONICA) |
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| YI Chuan-zhu,HU Yu-ming,CHEN Wei-lin,et al.. SAFETY ASSESSMENT OF LOQUAT LEAF(ERIOBOTRYA JAPONICA)[J]. Modern Preventive Medicine, 2010, 37(5) |
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| Authors: | YI Chuan-zhu HU Yu-ming CHEN Wei-lin et al. |
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| Affiliation: | YI Chuan-zhu,HU Yu-ming,CHEN Wei-lin,et al.(Hunan Provincial Center for Control , Prevention,Changsha 410005,China) |
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| Abstract: | [Objective] To research the acute genotoxicity and subchronic toxicity of Loquat leaf.[Methods] Test of maximum tolerated dose,Ames test,born marrow cell micronucleus test,mice sperm abnormality test and 90-day feeding study in rats were used to assess the safety of Loquat leaf.[Results] Its maximum tolerated dose(MTD) in mice was greater than 10.0g/kg.bw.Ames test,micronucleus test and sperm shape abnormality were negative.All the physiological indexes of the treated mice were normal in 90d feeding study.[... |
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| Keywords: | Loquat leaf Acute toxicity Genotoxicity Subchronic toxicity |
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