| 脂布福吉宁和乙酰毒毛花甙诱发离体浦肯野氏纤维延时性后去极化及触发性心律失常的比较(英文) |
| |
| 引用本文： | 解景田,Peter CUNNINGHAM,Stephen SHOROFSKY,AdrianaMOSCUCCI,ChrisCADMAN,Cr(?)TJANUARY. 脂布福吉宁和乙酰毒毛花甙诱发离体浦肯野氏纤维延时性后去极化及触发性心律失常的比较(英文)[J]. Acta pharmacologica Sinica, 1994, 0(2) |
| |
| 作者姓名： | 解景田 Peter CUNNINGHAM Stephen SHOROFSKY AdrianaMOSCUCCI ChrisCADMAN Cr(?)TJANUARY |
| |
| 作者单位： | Cardiac Electrophysiology Laboratories. Section of Cardiology，Department of Medicine，University of Chicago，Chicago，IL 60637，USA，Cardiac Electrophysiology Laboratories. Section of Cardiology，Department of Medicine，University of Chicago，Chicago，IL 60637，USA，Cardiac Electrophysiology Laboratories. Section of Cardiology，Department of Medicine，University of Chicago，Chicago，IL 60637，USA，Cardiac Electrophysiology Laboratories. Section of Cardiology，Department of Medicine，University of Chicago，Chicago，IL 60637，USA，Cardiac Electrophysiology Laboratories. Section of Cardiology，Department of Medicine，University of Chicago，Chicago，IL 60637，USA，Cardiac Electrophysiology Laboratories. Section of Cardiology，Department of Medicine，University of Chicago，Chicago，IL 60637，USA |
| |
| 基金项目： | Supported in part by National Heart,Lung，Blood Institute Grants HL 20592 and HL 38927，a Grant-in-Aid from Marquette Electronics Inc,Milwaukee WI,USA. |
| |
| 摘 要： | 用细胞外电图信号叠加技术微电极,于羊浦肯野纤维上,比较脂布福吉宁(RBG)(?)乙酰毒毛花甙元(AS)对诱发延时性后去极化(DAD)和触发性心律失常(TA)的作用,结果:1)低中毒剂量于刺激为990和690 ms时诱发出胞内和胞外的DAD;2)高中毒剂量诱发出DAD及TA,包含过早动作电位及触发性心动过速等;3)均引起动作电位振幅、静息电位及最大舒张期电位的降低、50％APD及Q-T间期的缩短,故RBG属于洋地黄类药物。
|
| 关 键 词： | 两栖动物毒 毒毛花甙元 心律失常 浦肯野纤维 动作电位 电生理学 |
Induction of delayed afterdepolarizations and triggered arrhythmias in isolated Purkinje fibers: comparison of resibufogenin and acetylstrophanthidin |
| |
| Jing-Tian XIE,Peter CUNNINGHAM,Stephen SHOROFSKY,Adriana MOSCUCCI,Chris CADMAN,Craig T JANUARY. Induction of delayed afterdepolarizations and triggered arrhythmias in isolated Purkinje fibers: comparison of resibufogenin and acetylstrophanthidin[J]. Acta pharmacologica Sinica, 1994, 0(2) |
| |
| Authors: | Jing-Tian XIE Peter CUNNINGHAM Stephen SHOROFSKY Adriana MOSCUCCI Chris CADMAN Craig T JANUARY |
| |
| Abstract: | |
| |
| Keywords: | amphibian venoms strophan- thidins arrhythmia Purkinje fibers action potentials electrophysiology |
| 本文献已被 CNKI 等数据库收录！ |
