云南宣威地区肺癌端粒酶RNA成分及Ki-67抗原的检测

目的　研究云南肺癌点状高发区--宣威地区组织学类型具有地方特征肺癌的发病机制。方法　以宣威地区29例肺癌和非宣威地区11例肺癌，应用免疫组化和原位分子杂交法分别检测Ki-67抗原和人端粒酶RNA成分(hTR)。结果　宣威地区肺癌组Ki-67标记率为34.4%±17.8%,明显高于非宣威地区肺癌组(21.9%±11.2%)，差异有显著性(P=0.045)；宣威地区肺癌组hTR检出率为55.2%，与非宣威地区组(72.7%)的差异无显著性(χ

Human telomerase RNA(hTR) expression and Ki-67 growth fraction in lung cancer in Xuanwei of Yunnan province

Objective　To investigate the pathogenesis o f lung cancer in population of Xuanwei with higher incidence and characteristic histologic type. Methods　 29 specimens of lung cancer from Xuanwei(Group X) and 11 specimens of lung cance r from other regions(Group NX) were detected for Ki-67 growth fraction and huma n telomerase RNA(hTR) expression by means of immunohistochemistry and in situ hy bridization respectively. Results　Ki-67 labeling index of Group X(34.4%±17.8%) was stati stically significantly higher than that of Group NX(21.9%±11.2%,P=0.045). No significant difference was observed with regard to the positive rate of hTR expression between Group X and Group NX(55.2% vs. 72.7%,P=0.31).However ,it was found that there was 45.5%(5/11) of patients with positive detection of hTR in the proliferating Ⅱ type alveolar epithlia adjacent to the cancer in Gro up NX. Conclusion　 The characteristic cause of lung cancer in Xuanwei may lead to its difference in cell kinetics from lung cancer of general people.hTR may be a valuable indicato r of lung malignancy for early diagnosis of lung cancer.