窄谱中波紫外线治疗寻常性银屑病疗效观察及血清细胞因子变化

目的：研究窄谱中波紫外线治疗寻常性银屑病的疗程、近期不良反应及预后；观察照射前后血清细胞因子浓度改变．探讨治疗机制。方法：给予86例寻常性银屑病患者窄谱中波紫外线(NB-UVB)照射，每周3次，共267次，用酶联免疫吸附试验检测32例患者治疗前后血清白介素-8(1L-8)、血管内皮细胞生长因子(VEGF)水平。结果：86例患者治疗后15例痊愈，临床有效率为93．2％，32例患者治疗前血清IL-8水平较健康对照者水平高，照射后显著下降。治疗前仪斑块状银屑病患血清清VEGF水平较正常人为高，照射后显著下降：结论：NB-UVB治疗银屑病疗效高、不良反应少，复发率低、IL-8水平升高可能为寻常性银屑病的发病机制之一。VEGF水平升高可能是斑块状银屑病致病的因素之一。

The clinical observation of narrow-band ultraviolet B for the treatment of psoriasis vulgaris and the kinetics of IL-8 and VEGF in serum

Objectives: To observe the therapeutic efficacy of narrow-band ultraviolet B(NB-UVB) for psoriasis and to investigate the kinetics of IL-8 and vascular endothelial growth factor (VEGF) in serum. Methods: Eighty-seven patients with psoriasis vulgaris were treated with NB-UVB which was performed three times per week, totally for 26 times. The serum levels of IL-8 and VEGF were also detected before and after the phototherapy in 32 patients. Results: After 26 time phototherapies, 15 patients were completely cured with a total clinical efficiency of 93.2%. Before the phototherapy the serum levels of IL-8 were higher in the patients than that in the normal health controls, which dropped down remarkably after NB-UVB irradiations. Same situation was found for VEGF detecting only in the patients with plaque psoriasis. Conclusions: UB-UVB phototherapy is a safe and effective method for the treatment of psoriasis, with a lower recurrence. The results suggested that IL-8 may play an important role in pathogenesis of psoriasis vulgaris, but high level of VEGF may be a key factor for plaque psoriasis.