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石榴叶鞣质对高血脂高血糖模型动物脂代谢的影响
引用本文:孟甄,孙立红,陈芸芸,叶敏,苏慧,邢东明,杜力军. 石榴叶鞣质对高血脂高血糖模型动物脂代谢的影响[J]. 中国实验方剂学杂志, 2005, 11(1): 22-24
作者姓名:孟甄  孙立红  陈芸芸  叶敏  苏慧  邢东明  杜力军
作者单位:清华大学生物科学与技术系药物药理研究室,北京,100084
基金项目:清华大学科技开发项目 (2 0 0 2 1 62 )
摘    要:目的 :观察石榴叶鞣质对高脂模型鼠脂代谢的影响 ,以及体外对HMG CoA还原酶的抑制作用。方法 :造大鼠高脂模型 ,以四氧嘧啶诱导高血糖伴高血脂小鼠模型 ,检测TC、TG等生化指标 ;制备大鼠肝微粒体HMG CoA还原酶液 ,测 1min内A34 0nm的变化。结果 :石榴叶鞣质大中剂量 (15 0、75mg kg)对高脂大鼠的TC和TG具有显著的降低作用 ,大小剂量 (30 0、75mg kg)对高血糖伴高血脂小鼠的TC降低作用明显 ,体外抑制HMG CoA还原酶的最低有效浓度为 1× 10 - 6 g mL ,抑制率 15 16 %。结论 :石榴叶鞣质对高脂模型鼠脂代谢紊乱具有较好的调节作用 ,体外可较强的抑制HMG CoA还原酶活性。

关 键 词:石榴叶鞣质 HMG-CoA还原酶 高脂模型
文章编号:1005-9903(2005)01-0022-03
收稿时间:2004-03-15
修稿时间:2004-03-15

The Effect of Pomegranate Leaf Tannide on Hyperlipidemic Models
MENG Zhen,SUN Li-hong,CHEN Yun-yun,YE Min,SU Hui,XING Dong-ming,DU Li-jun. The Effect of Pomegranate Leaf Tannide on Hyperlipidemic Models[J]. China Journal of Experimental Traditional Medical Formulae, 2005, 11(1): 22-24
Authors:MENG Zhen  SUN Li-hong  CHEN Yun-yun  YE Min  SU Hui  XING Dong-ming  DU Li-jun
Affiliation:Laboratory of Pharmaceutical Sciences,Department of Biological Sciences and Biotechnology,Tsinghua Universigy,Beijing 100084,China
Abstract:Objective:To explore the effect of pomegranate leaf tannide (PLT) on lipid metabolite of high-lipid rats and its inhibition on HMG-CoA reductasein vitro.Methods:The high-lipid rat model and high-lipid wiih high-sugar mice model induced by intraperitoneal injection of alloxan were used.The contents of TC and TG of both models was measured.Rat liver microsome HMG-CoA reductase was prepare to measure the content changes of A340in 1minute.Results:PLT can remarkably decrease TC and TG of high-lipid rat at doses of 150 and 75 mg/kg,and its reducing effect on TC of high-lipid with high-sugar mice at doses of 300 and 75mg/kg is also obvious.The minimal inhibition concentration of HMG-CoA reductasein vitrois 1×10-6g/mL with inhibition percentage of 15.16%.Conclusion: PLT has a noticeable activity of modulating lipid metabolite of high-lipid rat and inhibiting HMG-CoA redutasein vitro.
Keywords:Pomegranate leaf tannide  HMG CoA redutase  hyperlipidemic model
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