| 盐酸丁螺环酮缓释片的制备及其体外释放度考察 |
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| 引用本文： | 张韵,廖华卫. 盐酸丁螺环酮缓释片的制备及其体外释放度考察[J]. 中国药师, 2008, 11(6): 631-633 |
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| 作者姓名： | 张韵 廖华卫 |
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| 作者单位： | 1. 广州市药品检验所三分所,广州,510700
2. 广东药学院中药学院 |
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| 摘 要： | 目的制备盐酸丁螺环酮缓释片并探讨其体外释放机理.方法以羟丙基甲基纤维素(HPMC)为骨架材料,以乳糖、可压性淀粉、微晶纤维素调节释放度,采用正交试验法进行处方优化,用数学模型拟合释放曲线.结果HPMC、乳糖的用量对释药有显著性影响,盐酸丁螺环酮缓释片的体外释药符合零级释放模型.结论盐酸丁螺环酮缓释片处方设计合理,可进一步开发.
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| 关 键 词： | 盐酸丁螺环酮 缓释片 体外释放度 盐酸丁螺环酮缓释片 释放度 考察 in vitro Release Behavior Tablets Hydrochloride 开发 设计合理 处方优化 释放模型 零级 体外释药 影响 用量 结果 释放曲线 拟合 数学模型 正交试验法 |
| 文章编号： | 1008-049X(2008)06-0631-03 |
| 修稿时间： | 2007-11-12 |
Preparation of Buspirone Hydrochloride Sustained-Release Tablets and Release Behavior in vitro |
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| Zhang Yun,Liao Huawei. Preparation of Buspirone Hydrochloride Sustained-Release Tablets and Release Behavior in vitro[J]. China Pharmacist, 2008, 11(6): 631-633 |
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| Authors: | Zhang Yun Liao Huawei |
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| Affiliation: | Zhang Yun (Third Branch of Institute for Drug Control of Guangzhou City,Guangzhou 510700,China),Liao Huawei (Guangdong Pharmaceutical College) |
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| Abstract: | Objective:To prepare sustained release tablets of buspirone hydrochloride and study the release mechanism.Method: HPMC was used as the gel matrix.Lactose,starch and MCC were used to modify the release.Orthogonal experiment was carried out to optimize the formulation.Mathematic models were used to imitate the drug release.Result:The amount of HPMC and lactose had sig- nificant effects on the release of buspirone hydrochloride.The release behavior of the tablets followed the zero order equation.Conclu- sion:T... |
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| Keywords: | Buspirone hydrochloride Sustained-release tablets Release rate in vitro |
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