| 电刺激VSA对IL-1β作用下兔POAH温敏神经元放电的影响关 |
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| 引用本文： | 董军,李楚杰.电刺激VSA对IL-1β作用下兔POAH温敏神经元放电的影响关[J].中国病理生理杂志,2000,16(4):301-303. |
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| 作者姓名： | 董军 李楚杰 |
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| 作者单位： | 暨南大学医学院病理生理教研室, 广东 广州 510632 |
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| 基金项目： | 国家自然科学基金资助(No.39600061);国务院侨办科学基金资助(No. 93-95-8);本文在全国炎症、发热、感染、低温学术会议上宣读,获青年优秀论文壹等奖 |
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| 摘 要： | 目的和方法:本实验采用微电极细胞外记录,在32只新西兰兔下丘脑视前区(POAH)记录温敏神经元单位放电,观察电刺激腹中膈区(VSA)对致热原IL-1β作用下兔POAH温敏神经元放电的影响。结果:(1)侧脑室注射白介素-1β(IL-1β)能使POAH热敏神经元放电减少,冷敏神经元放电增加;而侧脑室注射人工脑脊液(ACSF)对热敏神经元和冷敏神经元的放电均无明显影响。(2)电刺激VSA可反转IL-1β对POAH热敏神经元和冷敏神经元的上述作用。结论:VSA可能作为负调节中枢参与致热原作用下的体温调节。
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| 关 键 词： | 隔核 视前区 前下丘脑区 体温调节 白细胞介素-1 电生理学 |
| 收稿时间： | 1999-10-15 |
Effects of electrical stimulation of ventral septal area on discharge of pyrogen-treated thermosensitive neurons in preoptic anterior hypothalamus region of rabbits |
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| DONG Jun,LI Chu-jie,LU Da-xiang,FU Yong-mei,YAN Liang.Effects of electrical stimulation of ventral septal area on discharge of pyrogen-treated thermosensitive neurons in preoptic anterior hypothalamus region of rabbits[J].Chinese Journal of Pathophysiology,2000,16(4):301-303. |
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| Authors: | DONG Jun LI Chu-jie LU Da-xiang FU Yong-mei YAN Liang |
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| Institution: | Department of Pathophysiology, Medical College of Jinan University, Guangzhou 510632, China |
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| Abstract: | AIM and METHODS: To investigate the effect of electrical stimulation of ventral septal area (VSA) on discharge of pyrogen-treated thermosensitive neurons in preoptic anterior hypothalamus (POAH) region, the discharging rate of thermosensitive neurons in the POAH region of 32 New Zealand white rabbits were recorded by using extracellular microelectrode techinque. RESULTS: (1) Intraceretroventricularly (i c v) injection of interleukin-1β(IL-1β) caused decrease of discharging rate of warm-sensitive neurons and increased in discharging rate of cold-sensitive neurons in POAH regions. (2) These effects could be reversed by electrical stimulation of VSA. CONCLUSION: VSA may play a central role of negative regulation in thermoregulation of pyrogen-treated animal. |
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| Keywords: | Septal nuclei Preoptic area Anterior hypothalamic area Body themperature regulation Interleukin-1 Electrophysiology |
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