| HPLC法测定维库溴铵含量及有关物质 |
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| 引用本文： | 杜宁. HPLC法测定维库溴铵含量及有关物质[J]. 齐鲁药事, 2012, 31(6): 337-338 |
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| 作者姓名： | 杜宁 |
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| 作者单位： | 江苏省食品药品检验所,江苏,南京,210008 |
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| 摘 要： | 目的建立维库溴铵含量及有关物质的高效液相色谱测定方法。方法以C18柱,0.3 M甲酸铵溶液-甲醇(40∶60)为流动相,流速为1.0 mL·min-1,柱温30℃,检测波长为210 nm。结果在浓度为20.0～1 000.1μg·mL-1范围内,本法线性关系良好,相关系数r=0.999 5(n=7),有关物质分离较好。结论该方法简单,准确,可以作为维库溴铵含量和有关物质的测定方法。
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| 关 键 词： | 维库溴铵 含量测定 有关物质 高效液相色谱法 |
Determination of vecuronium bromide and its related substances by HPLC |
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| DU Ning. Determination of vecuronium bromide and its related substances by HPLC[J]. qilu pharmaceutical affairs, 2012, 31(6): 337-338 |
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| Authors: | DU Ning |
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| Affiliation: | DU Ning(Jiangsu Institute for Food and Drug Control,Nanjing 210008,China) |
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| Abstract: | Objective To establish an HPLC method for the determination of vecuronium bromide and its related substances.Methods The determination was carried out on a C18 column and the mobile phase was 0.3 M ammonium formate solution-methanol(40∶ 60)at flow rate of 1.0 mL·min-1.The column temperature was 30 ℃ and the detection wavelength was 210 nm.Results A good linearity and separation can be obtained within the range of 20.0～1 000.1 μg· mL-1(r=0.999 5,n=7).Conclusion The method was simple and accurate,and it can be used for the determination of vecuronium bromide and its related substances. |
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| Keywords: | Vecuronim bromide Determination Related substances HPLC |
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