| 金属配合物与G-四链体作用的研究进展 |
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| 引用本文： | 孙静,陈嘉曦,陈伙炎,毛宗万.金属配合物与G-四链体作用的研究进展[J].中国药理学通报,2012,28(4):469-472. |
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| 作者姓名： | 孙静 陈嘉曦 陈伙炎 毛宗万 |
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| 作者单位： | 1. 广东医学院药学院,广东东莞,523808
2. 中山大学化学化工学院,生物无机与合成化学教育部重点实验室,广东广州510275 |
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| 基金项目： | 国家自然科学基金资助项目(No 21101034);东莞市科技计划项目(No 2011108102046) |
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| 摘 要： | 端粒DNA形成的独特二级结构G-四链体对端粒酶的活性有明显抑制作用,能达到促进肿瘤细胞凋亡的作用。研究表明,能够诱使端粒DNA形成G-四链体及可以稳定这种结构的药物均可能成为有效的化疗药物。金属配合物由于其合成路径简单、结构多变、金属中心所携带的正电荷有利于与G-四链体的沟区、loop环以及带负电荷的磷酸骨架作用,增强其稳定性,因此越来越多的过渡金属配合物被设计用来研究与G-四链体作用。该文综述了近年来金属配合物与G-四链体DNA相互作用方面的研究进展。
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| 关 键 词： | 金属配合物 端粒酶抑制剂 DNA G-四链体 致癌基因 抗肿瘤药物 |
Interaction of metal complexes with G-quadruplex |
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| SUN Jing
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CHEN Jia-xi
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CHEN Huo-yan
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MAO Zong-wan.Interaction of metal complexes with G-quadruplex[J].Chinese Pharmacological Bulletin,2012,28(4):469-472. |
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| Authors: | SUN Jing CHEN Jia-xi CHEN Huo-yan MAO Zong-wan |
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| Institution: | 1.School of Pharmacy,Guangdong Medical College,Dongguan Guangdong 523808,China;2.MOE Key laboratory of Bioinorganicand Synthetic Chemistry,School of Chemistry and Chemical Engineering,Sun Yat-Sen University,Guangzhou 510275,China) |
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| Abstract: | The activity of telomerase can be prohibited by the secondary structure of the telomere DNA-G-quadruplex formed by the single chain in G-rich field,resulting in the apoptosis in tumor cells.Compound which can induce the formation or stabilize the structure of G-quadruplex might be potential anticancer drug.The relative ease of synthesis,the variable structure and the positively charged center enable the metal complexes to interact with the grooves and loops of the quadruplex and negatively charged phosphates backbone.Therefore,many metal complexes have been designed and synthesized.This paper reviews the discoveries in the interaction of G-quadruplex with metal complexes in the past years. |
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| Keywords: | metal complexes telomerase inhibitor DNA G-quadruplex oncogene anti-tumor drugs |
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