| 肾脏水通道蛋白2“穿梭机制”的研究进展 |
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| 引用本文： | 朱妍,焦悦,李守业,李昌煜. 肾脏水通道蛋白2“穿梭机制”的研究进展[J]. 中国药理学通报, 2012, 28(4): 451-455 |
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| 作者姓名： | 朱妍 焦悦 李守业 李昌煜 |
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| 作者单位： | 浙江中医药大学药学院,浙江杭州,310053 |
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| 基金项目： | 国家自然科学基金资助项目(No 81173143) |
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| 摘 要： | AQP2是水通道蛋白家族成员之一,在肾脏尿液浓缩、稀释功能和维持体内水平衡中发挥着重要作用。该文根据近年来有关AQP2的研究结果,介绍了AQP2穿梭机制的信号转导途径,同时阐述了其调控因素,包括AQP2磷酸化、细胞骨架的作用、含AQP2囊泡融合膜顶端、AQP2结合蛋白等,为今后以AQP2为靶点的临床治疗提供理论基础。
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| 关 键 词： | 水通道蛋白2 穿梭机制 信号转导途径 抗利尿激素 囊泡 磷酸化 |
The research progress of kidney aquaporin-2 trafficking mechanism |
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| ZHU Yan , JIAO Yue , LI Shou-ye , LI Chang-yu. The research progress of kidney aquaporin-2 trafficking mechanism[J]. Chinese Pharmacological Bulletin, 2012, 28(4): 451-455 |
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| Authors: | ZHU Yan JIAO Yue LI Shou-ye LI Chang-yu |
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| Affiliation: | (College of Pharmaceutical Science,Zhejiang Traditional Chinese Medicine University,Hangzhou 310053,China) |
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| Abstract: | Aquaporin-2(AQP2) is one of the members in the aquaporin family,which plays an important role for urine concentration in the kidney,dilution function and maintainance of water balance in the body.Based on relative researches on AQP2 in recent years,the review aims to introduce the signal transduction pathways of AQP2 trafficking mechanism and elaborate on the regulatory factors,including the phosphorylation of AQP2,the role of cytoskeleton,fusion of AQP2 containing vesicles with apical membrane,and AQP2 binding proteins,thus provide theoretical basis for AQP2 targeted clinical treatment. |
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| Keywords: | AQP2 trafficking mechanism signal transduction pathway antidiuretic hormone vesicle phosphorylation |
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