固体分散技术提高枸橼酸莫沙必利片溶出度的研究

目的考察固体分散技术对枸橼酸莫沙必利片的体外溶出度的影响。方法以聚维酮K30为载体制备枸橼酸莫沙必利片固体分散体,紫外分光光度法对其体外溶出度进行测定。结果聚维酮K30-枸橼酸莫沙必利比例大于2∶1(w/w)时所得枸橼酸莫沙必利片5 min累积溶出量接近100%,而市售品溶出缓慢,5 min累积溶出量约为50%,30min累积溶出量约为90%。结论采用固体分散技术制备的枸橼酸莫沙必利片能显著提高枸橼酸莫沙必利的溶出速率。

Study on improvement of the dissolution rate of Mosapride Citrate Tablet by using solid dispersion technique

Objective To investigate the effect of solid dispersion technique on the dissolution rate of Mosapride Citrate Tablet.Methods The solid dispersion of Mosapride Citrate Tablet was prepared with providone K30 as carrier,and the dissolution rate in vitro was determined by UV spectrophotometry.Results The cumulative dissolution was about 100% in 5 min when the ratio of providone K30 mosapride citrate was above 2∶ 1.The cumulative dissolution of market drug was only 50% in 5 min,and about 90% in 30 min.Condusion Solid dispersion technique can significantly improve the dissolution rate of Mosapride Citrate Tablet.