快速老化小鼠SAMP10的老化特征及其研究进展

快速老化小鼠(senescence-accelerated mouse,SAM)是日本京都大学Takeda教授从AKR/J系小白鼠中通过表型选择培育出的快速老化模型。根据老化速度和病状特征,SAM鼠可以分为快速衰老的P系和抗快速老化的R系。快速老化小鼠SAMP10作为P系的一种,主要特征表现为与衰老相关的学习记忆障碍,具有β-淀粉样蛋白沉积、脑萎缩、神经DNA损伤、星形胶质细胞及小胶质细胞增生等病理变化,在行为学、神经递质以及分子水平方面均表现出一定的衰老变化,是目前较理想的研究阿尔采末病(AD)的动物模型。同龄对照组SAMR1具有正常的衰老特征,常用于SAMP10的正常对照。目前SAMP10是比较理想的用于研究学习记忆障碍的发病机制、评价抗衰老药物以及抗抑郁药的动物模型。

Aging characteristics and progress in studies on senescence accelerated mouse prone 10(SAMP10)

The senescence-accelerated mouse have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by Professor Takeda coming from Kyoto University in Japan.By aging characteristics,the SAM strains may divide into senescence-prone inbred strains(SAMP) and senescence-resistant inbred strains(SAMR).As a strain of SAMP strains,the characteristics of senescence-accelerated mouse prone 10(SAMP10) is aging-related impairment of learning and memory defects.The characteristics of senescence-accelerated mouse prone 10(SAMP10) is considered an effective model for studying Alzheimer’s disease(AD),which has some pathological characteristics such as beta-amyloid deposition,brain atrophy,nerve DNA damage,astrocytes and microglial cell proliferation,and it has shown certain aging changes in behavior,neurotransmitter and molecular levels.The SAMR1 strain is usually used a normal control model which exhibits normal aging characteristics.The SAMP10 can be used as an animal model for the study of revealing mechanism of accelerated deficits in learning and memory,and evaluating of anti-aging drugs and antidepressant drugs.