| 雷奈酸锶的合成 |
| |
| 引用本文： | 徐彦,苏曼,曲春生.雷奈酸锶的合成[J].齐鲁药事,2012,31(6):323-324,330. |
| |
| 作者姓名： | 徐彦 苏曼 曲春生 |
| |
| 作者单位： | 1. 山东司邦得制药有限公司,山东,济南,250216
2. 山东铂源药业有限公司,山东,济南,251400 |
| |
| 摘 要： | 目的研究雷奈酸锶的化学合成。方法以无水柠檬酸为起始原料,经脱羧、酯化、环合、烷基化、水解和成盐等多步反应生成最终产物雷奈酸锶。结果雷奈酸锶的结构经IR1、H-NMR1、3C-NMR得到证实,总产率为41.4%。结论本合成路线操作简单,成本低,纯度高,适合工业化生产。
|
| 关 键 词： | 雷奈酸锶 骨质疏松 合成 |
Synthesis of strontium ranelate |
| |
| XU Yan
,
SU Man
,
QU Chun-sheng.Synthesis of strontium ranelate[J].qilu pharmaceutical affairs,2012,31(6):323-324,330. |
| |
| Authors: | XU Yan SU Man QU Chun-sheng |
| |
| Institution: | 1. Shandong Sibangde Pharmaceutical Co. , Ltd. , Jinan 250216, China ;2. Shandong Boyuan Pharmaceutical Co. , Ltd. , Jinan 251400, China ) |
| |
| Abstract: | Objective To study the synthesis of strontium ranelate. Methods The strontium ranelate was synthesized from citric acid by decarboxylation, esterification, cyclization, alkylation, hydrolyzation and then salt formation. Results The structure of strontium ranelate was confirmed by IR, ^1 H - NMR,^13 C - NMR and the total yield was approximately 41.4%. Conclusion This synthesis route was simple with low cost and high purity, and it was suitable for industrial production. |
| |
| Keywords: | Strontium ranelate Osteoporosis Synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
