肾病综合征患者血浆同型半胱氨酸和血清叶酸、维生素B12的含量变化及其临床意义

目的检测肾病综合征（PNS）患者血浆同型半胱氨酸（Hcy）和血清叶酸、维生素B12（VitB12）的变化并探讨其临床意义。方法采用高效液相色谱一荧光检测法测定PNS患者血清Hcy浓度，Access全自动微粒子发光仪测定其血清中的叶酸和VitB12含量。结果PNS患者血浆Hcy含量显著高于对照组，VitB12含量显著低于对照组，叶酸的含量与对照组比较差异无显著性。血浆Hcy浓度与内生肌酐清除率和24h尿蛋白排泄量有相关性。结论高Hcy和低VitB12参与PNS的发病过程，是PNS患者发生心血管功能紊乱的危险因素。

Significance of Plasma Homocysteine,Folates and Vitamin B12 in Patients with Primary Nephritic Syndrome

Objective To investigate the clinical significance of serum homocysteine, folates and vitamin B12 in patients with nephrotic syndrome. Methods The level of serum homocysteine was detected by high performance liquid chromatography（HPLC）. The contens of folates and vitamin B12 were determined by chemolu- minescenc method. Results The serum homocysteine level was higher, and vitamin B12 level was lower in nephritic patients than those in controls. But no statistically significant difference in folate level was observed between the two study groups. The serum homocysteine level was negatively corrected to proteinuria, and positively related to creatinine clearance. Conclusion The serum homoeysteine and vitamin B12 participate in the occurrence and development of primary nephritic syndrome. Homocysteinemia is a possible risk factor in nephritic syndrome with cardiovascular dysfunction.