细胞色素氧化酶P450及其遗传多态性

细胞色素氧化酶P45 0是药物代谢中的一个重要的酶系。近年来 ,对细胞色素P45 0氧化酶与药物氧化代谢多态性的关系进行了研究。CYP2C19与CYP2D6等在表型和基因型水平上均发现存在氧化代谢多态性 ,并对其分子机制有了深入的了解 ,而CYP2C9,CYP1A1等其他酶可能存在多态性 ,但其分子机制尚不清楚。本文综述了这些P45 0酶的底物 ,种族差异 ,遗传多态性 ,以及其对药物代谢和疾病易感性的影响

Cytochrome P450 and genetic polymorphism

Cytochrome P450 enzyme are an important enzyme family in drug metabolism. Human cytochrome P450 enzymes have been studied entensively about their polymorphism in recent years. polymorphism of CYP2C19 and CYP2D6 have been detected at both phenotypic and genotypic level, and their molecular mechanism have been studied entensively, however, the molecular mechanism of other enzymes for exzample CYP2C9,CYP1A1,CYP2E1 et al ) is being discussed, though these enzymes possiblely exist polymorphism. The article summarizes the substrates of P450, molucular mechanism of polymorphism, and paticular reference to the effects of this variation on drug metabolism and susceptibility to chemically induced diseases.