北京市通州区6月龄儿童麻疹疫苗免疫效果分析

目的探讨麻疹疫苗的初免月龄提前至6月龄的可行性。方法通过与8月龄婴儿的比较,分析6月龄婴儿的免后麻疹IgG抗体滴度、阳转率。结果免疫前IgG滴度,6月龄免前麻疹IgG滴度高于8月龄,只有6.06%的6月龄婴儿处于低保护水平;免疫后6月龄、8月龄婴儿麻疹IgG滴度平均分别为751.44mIU/ml、1076.14mIU/ml,8月龄的免后麻疹IgG滴度高于6月龄(P=0.003);6月龄、8月龄免后麻疹IgG阳转率分别为93.55%、96.88%,差异无统计学意义(P=0.978)。结论6月龄以后的婴幼儿处于麻疹易感状态,在现有2剂(8月龄、1.5岁)麻疹疫苗免疫的基础上,将初免月龄提前至6月龄,既能保证麻疹疫苗的高覆盖率,又能减少小年龄组的麻疹发病率。

Efficacy of measles vaccine in six-month-old babies in Tongzhou District, Beijing

Objective To evaluate the feasibility of measles vaccine immunization in babies at six months old.Methods Titers of measles IgG antibody and serum antibody conversion rate after measles immunization were compared in babies immunized at six month old with those immunized at eight months old.Results Before immunization,titer of measles IgG antibody in babies at six months old was higher than that in those at eight months old,and only 6.06% of the babies of six months old with lower level of immunological protection.After basic immunization,mean titer of measles IgG antibody was 751.44 mIU/ml and 1?076.14 mIU/ml for babies at six months old and at eight months old,respectively,with statistically significant difference(P=0.003),and serum antibody conversion rate was 93.55% and 96.88%,respectively,but without statistically significant difference(P=0.978).Conclusion Babies after their six months are all susceptible to measles.The first measles immunization at six months old can guarantee higher coverage of the vaccine and reduce its morbidity in small-month babies.