E-cadherin、C-erbB-2在胃癌中的表达特点及意义

目的探讨E-cadherin和C-erbB-2蛋白表达与胃癌分化转移的关系。方法应用免疫组织化学S-P法检测67例胃癌组织和15例正常胃组织中E-cadherin、C-erbB-2的表达,并分析它们与胃癌临床病理特征的关系。结果67例胃癌中E-cadherin和C-erbB-2蛋白阳性表达率分别为49.25%(33/67)和46.27%(31/67)。C-erbB-2高表达及E-cadherin低表达与胃癌的分化程度和淋巴结转移均呈正相关(P<0.05)。结论C-erbB-2和E-cadherin表达与胃癌的浸润转移密切相关,是判断胃癌生物学行为及预后的重要指标。

Expression feature and significance of E-cadherin and C-erbB-2 in gastric carcinoma

Objective To explore feature the expression of E-cadherin and C-erbB-2 protein in gastric carcinoma.Methods The expression of E-cadherin and C-erbB-2 protein in 67 cases with gastric carcinoma and 26 cases normal gastric tissues were examined by immunohis-tochemical S-P method and the relationship between their expression and clinica1pathologicalparameters was analyzed.Results The positive rates of E-cadherin and C-erbB-2 protein staining in 67 cases of gastric carcinoma were 49.25%(33/67)and 46.27%(31/67) respectively.The high level of C-erbB-2 expression and the low level of E-cadherin expression were positively corre1ated with differentiation degree and lymph node metastasis in gastric carcinoma(P <0.05).Conclusion C-erbB-2 overexpression and reduced E-cadherin expression were associated significantly with the invasion and metastasis of gastric carcinoma..The combined detection of E-cadherin and C-erbB-2 protein may be valuable in predicting the biological behavior of gastric carcinoma.