| 正常皮肤银屑病皮损和皮肤鳞癌组织酪氨酸蛋白激酶活性的研究 |
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| 引用本文： | 吕根法,李文维,伍津津.正常皮肤银屑病皮损和皮肤鳞癌组织酪氨酸蛋白激酶活性的研究[J].中国皮肤性病学杂志,1999(5). |
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| 作者姓名： | 吕根法 李文维 伍津津 |
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| 作者单位： | 解放军534医院皮肤科!洛阳，471000，第三军医大学大坪医院皮肤科，第三军医大学大坪医院皮肤科 |
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| 摘 要： | 目的 探讨角质形成细胞异常增生的发病机理。方法 通过外源性底物磷酸化方法，测定了１６ 例正常皮肤、２２ 例银屑病皮损、５ 例皮肤鳞癌组织角质形成细胞膜酪氨酸蛋白激酶（ Ｔ Ｐ Ｋ） 的活性。结果 角质形成细胞膜 Ｔ Ｐ Ｋ 活性在银屑病和癌组织中显著增高，且癌组织又明显高于银屑病皮损。结论 提示 Ｔ Ｐ Ｋ 活性的异常可能在角质形成细胞的异常增生中起重要作用。
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| 关 键 词： | 银屑病 皮肤鳞癌 酪氨酸蛋白激酶 |
Studies on Tyrosine Protein Kinase in Normal Skin,Psoriatic Lesion and Skin Squamous Carcinoma. |
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| Lu Genfa,Li Wenwei,Wu Jinjin.Studies on Tyrosine Protein Kinase in Normal Skin,Psoriatic Lesion and Skin Squamous Carcinoma.[J].The Chinese Journal of Dermatovenereology,1999(5). |
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| Authors: | Lu Genfa Li Wenwei Wu Jinjin |
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| Institution: | Lu Genfa,Li Wenwei,Wu Jinjin.Department of Dermatology 534 Hospital of PLA,Luoyang,471003 |
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| Abstract: | Objective To study the pathogenesis of abnormal proliferation of keratinocytes.Method The activity of tyrosine protein kinase(TPK) was determined by using exogenic substrates in 16 samples of normal skin,22 psoriatic lesion and 5 skin squamous carcinoma.Result The activity of TPK was significntly increased in psoriatic lesion and skin squamous carcinoma,and even higher in carcinoma.Conclusion The increased activity of TPK may play an important role in keratinocyte hyperproliferation. |
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| Keywords: | Psoriasis Squamous carcinoma Tyrosine protein kinase |
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