新生隐球菌L型致病性的实验研究

以稳定新生隐球菌Ｌ型感染小鼠后，部分脑组织中出现长丝体和巨形体。病原分离，新生隐球菌大小不一、形态不规则。病理学检查，各脏器主要表现为间质性炎症。我们认为：①新生隐球菌Ｌ型致病的特征性表现为间质性炎症；②隐球菌性肉芽肿的形成可能与病灶处新生隐球菌变异成Ｌ型有关。

Pathogenicity of L-forms of Cryptococcus Neoformans in Mice

Mice were injected intracranially with stable Cryptococcus neoformans L-forms. The results showed that filamentous or large bodies could be found in the brains of some mice. Pathogenetic examinations indicated that C. neoformans isolated from these mice were different in size and irregular in shape on the solid hypertonic media. The characteristic pathological feature seen in main internal organs was interstitial changes accompanied by gathering of chronic inflammatory cells. The results demonstrate that: (1 ) The interstitial changes are significant feature of C. neoformans L-forms infection; (2) The infection of C. neoformans is mainly via respiratory tract where the pathogens turn into L-forms with the induction of macrophages and lysozyme ;therefore the pathological change of most pulmonary cryptococcosis is in the form of interstitial pneumonia; (3) the gathering of chronic inflammatory cells during the L-forms infection may be the cause of cryptococcal granulomas.