子宫内膜厚度对IVF-ET妊娠结局的影响

目的探讨行体外受精-胚胎移植(IVF-ET)患者中,不同子宫内膜厚度对妊娠结局的影响。方法回顾性分析2016年1月至2017年12月在该院遗传与生殖研究所行新鲜胚胎移植的患者2981例。根据子宫内膜厚度分为5组:A组80例,子宫内膜厚度为7 mm;B组908例,子宫内膜厚度8~9 mm;C组1379例,子宫内膜厚度10~11 mm;D组542例,子宫内膜厚度12~13 mm;E组72例,子宫内膜厚度≥14 mm。比较各组胚胎着床率、临床妊娠率、异位妊娠率、临床流产率、分娩率、单胎率、双胎率等IVF-ET助孕结局。结果各组年龄、体质量指数(BMI)、促排卵药物(GN)用量、GN用药天数、平均获卵数、可移植胚胎数等比较,差异无统计学意义(P>0.05);不同组间妊娠率、异位妊娠率、临床流产率、畸形率比较,差异无统计学意义(P>0.05)。E组胚胎着床率、双胎率显著高于A组,单胎率显著低于A组,差异均有统计学意义(P<0.05);C组分娩率显著高于A组,差异有统计学意义(P<0.05)。各组患者妊娠结局比较,差异均无统计学意义(P>0.05)。结论改善子宫内膜厚度有助于改善妊娠结局,子宫内膜厚度越厚,此时胚胎着床可能性越大;子宫内膜厚度的变化不会增加IVF-ET出生婴儿的安全风险。

Effect of endometrial thickness on pregnancy outcome of IVF-ET

Objective To investigate the effect of endometrial thickness on pregnancy outcome during fresh embryo transfer cycle of in vitro fertilization-embryo transfer(IVF-ET).Methods A total of 2981 cases of fresh embryo transfer(ET)in the Chongqing Maternal and Child Health Hospital from January 2016 to December 2017 were analyzed.According to the thickness of endometrium,they were divided into five groups:group A(n=80),thickness of endometrium was 7 mm;group B(n=908),thickness of endometrium was 8-9 mm;group C(n=1379),thickness of endometrium was 10-11 mm;group D(n=542),thickness of endometrium was 12-13 mm and group E(n=72),thickness of endometrium was more than 14 mm.The embryo implantation rate,clinical pregnancy rate,ectopic pregnancy rate,clinical abortion rate,delivery rate,singleton rate and twin rate were compared.Results There were no significant difference of age,body mass index(BMI),amount of gonadotropin,days of gonadotropin,number of eggs,number of transplantable embryos among different groups(P>0.05).There were significant differences in clinical pregnancy rate,ectopic pregnancy rate,abortion rate and malformation rate among different groups(P>0.05).The implantation rate and twin rate of group E were significantly higher than that of group A(P<0.05),while the singleton rate of group E was significantly lower than that of group A(P<0.05).The delivery rate in group C was significantly higher than that of group A(P<0.05).The pregnancy outcomes among different groups had no differences(P>0.05).Conclusion Improving endometrial thickness is helpful to improve pregnancy outcomes,the thicker the endometrial thickness,the more probable of embryo implantation.And the changes of endometrial thickness would not increase the risk of newborn babies of IVF-ET.