绵阳地区妊娠期妇女25-羟维生素D水平的调查分析

目的了解绵阳地区妊娠期妇女(以下简称孕妇)25-羟维生素D[25(OH)D]水平,为临床科学指导维生素D补充提供依据。方法选择2017年9月至2019年5月在该院进行产检的健康孕妇3346例为研究对象,采用超高效液相色谱-串联质谱法(UPLC-MS/MS)检测血清25(OH)D水平,分析孕妇25(OH)D水平缺乏与不足情况。结果绵阳地区孕妇血清25(OH)D平均水平为(22.76±6.63)ng/mL;血清25(OH)D缺乏、不足与均衡人数分别为1191例(35.6%)、1710例(51.1%)、445例(13.3%)。孕早、中、晚期血清25(OH)D平均水平分别为(23.05±6.48)、(22.46±6.62)、(22.85±7.12)ng/mL,孕早、中期比较,差异有统计学意义(P<0.05)。不同年龄段孕妇25(OH)D缺乏率、不足率和均衡率比较,差异无统计学意义(P>0.05)。春、夏、秋、冬四季血清25(OH)D平均水平分别为(24.11±6.44)、(23.21±5.75)、(22.88±6.74)、(21.03±6.83)ng/mL;不同季节25(OH)D缺乏率与不足率比较,差异均有统计学意义(P<0.05)。结论绵阳地区孕妇普遍存在维生素D缺乏或不足情况,冬季尤为显著,应重视维生素D的科学补充,以预防维生素D缺乏。

Analysis on vitamin D level of pregnant women in Mianyang area

Objective To investigate the serum level of 25-hydroxy vitamin D[25(OH)D]in pregnant women in Mianyang area,for the guidance of vitamin D supplements in pregnancy.Methods A total of 3346 healthy pregnant women underwent a birth checkup at the hospital from September 2017 to May 2019 were selected as the research subjects.Ultra performance liquid chromatography-mass spectrometry(UPLC-MS/MS)method was used to detect the level of serum 25(OH)D.The deficiency and insufficiency of 25(OH)D in pregnant women were analyzed.Results The average serum 25(OH)D level was(22.76±6.63)ng/mL of pregnant women in Mianyang area.Serum 25(OH)D deficiency,insufficiency and balance were 1191(35.6%),1710(51.1%)and 445(13.3%)respectively.The levels of serum 25(OH)D in early,middle and late pregnancy were(23.05±6.48),(22.46±6.62),(22.85±7.12)ng/mL respectively,and there was significant difference between early and middle pregnancy(P<0.05).The rates of 25(OH)D deficiency,insufficiency and balance in different age groups had no significant differences(P>0.05).The average levels of serum 25(OH)D in spring,summer,autumn and winter were(24.11±6.44),(23.21±5.75),(22.88±6.74),(21.03±6.83)ng/mL respectively.The rates of 25(OH)D deficiency and insufficiency were statistically different in 4 seasons(P<0.05).Conclusion Vitamin D deficiency or insufficiency is common in pregnant women of Mianyang area,and more serious in winter.More attention should be put on scientific guidance of vitamin D supplement for prevention of vitamin D deficiency.